{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:00:50Z","timestamp":1786708850609,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to explore the predictive value of CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score for in\u2010hospital major adverse cardiac events (MACEs) in ST\u2010elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary artery intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 746 STEMI patients were divided into four groups according to CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score (1, 2\u20133, 4\u20135, &gt;5). The predictive ability of the CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score for in\u2010hospital MACE was made. Subgroup analysis was made between gender differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a multivariate logistic regression analysis model including creatinine, total cholesterol, and left ventricular ejection fraction, CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score was an independent predictor of MACE as a continuous variable (adjusted odds ratio: 1.43, 95% confidence interval [CI]: 1.27\u20131.62, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). As a category variable, using the lowest CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score of 1 as a reference, CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score 2\u20133, 4\u20135, &gt;5 groups for predicting MACE was 4.62 (95% CI: 1.94\u201311.00, <jats:italic>p<\/jats:italic>\u2009=\u2009.001), 7.74 (95% CI: 3.18\u201318.89, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and 11.71 (95% CI: 4.14\u201333.15, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score was also an independent risk factor for MACE in the male group, either as a continuous variable or category variable. However, CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score was not a predictor of MACE in the female group. The area under the curve value of the CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score for predicting MACE was 0.661 in total patients (74.1% sensitivity and 50.4% specificity [<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001]), 0.714 in the male group (69.4% sensitivity and 63.1% specificity [<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001]), but there was no statistical significance in the female group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score could be considered as a potential predictor of in\u2010hospital MACE with STEMI, especially in males.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24071","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T04:45:05Z","timestamp":1689050705000},"page":"950-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predictive value of CHA<sub>2<\/sub>DS<sub>2<\/sub>\u2010VASc score for in\u2010hospital prognosis of patients with acute ST\u2010segment elevation myocardial infarction undergoing primary PCI"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0826-8338","authenticated-orcid":false,"given":"Ying","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiology, Liaocheng People's Hospital Shandong University Jinan Shandong P.R. China"},{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong P.R. China"},{"name":"Department of Cardiology, Liaocheng Dongchangfu People's Hospital Liaocheng People's Hospital Liaocheng Shandong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Liaocheng People's Hospital Shandong University Jinan Shandong P.R. China"},{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Liaocheng People's Hospital Shandong University Jinan Shandong P.R. China"},{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Liaocheng People's Hospital Shandong University Jinan Shandong P.R. China"},{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0291-8723","authenticated-orcid":false,"given":"Hengchen","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Liaocheng People's Hospital Shandong University Jinan Shandong P.R. China"},{"name":"Department of Cardiology Liaocheng People's Hospital Affiliated to Shandong First Medical University Liaocheng Shandong P.R. 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