{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:21:13Z","timestamp":1790785273156,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","award":["2020006"],"award-info":[{"award-number":["2020006"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elevated N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP) concentrations predict heart failure (HF) and mortality, but whether NT\u2010proBNP predicts ventricular arrhythmias (VA) is not clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>We hypothesize that high NT\u2010proBNP concentrations associate with the risk of incident VA, defined as adjudicated ventricular fibrillation or sustained ventricular tachycardia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a prospective, observational study of patients treated with implantable cardioverter defibrillator (ICD), we analyzed NT\u2010proBNP concentrations at baseline and after mean 1.4 years in association to incident VA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 490 patients (age 66\u2009\u00b1\u200912 years, 83% men) out of whom 51% had a primary prevention ICD indication. The median NT\u2010proBNP concentration was 567 (25\u201375 percentile 203\u20131480)\u2009ng\/L and patients with higher concentrations were older with more HF and ICD for primary prevention. During mean 3.1\u2009\u00b1\u20090.7 years, 137 patients (28%) had \u22651 VA. Baseline NT\u2010proBNP concentrations were associated with the risk of incident VA (hazard ratio [HR]: 1.39, 95% confidence interval [95% CI]: 1.22\u20131.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), HF hospitalizations (HR: 3.11, 95% CI: 2.53\u20133.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), and all\u2010cause mortality (HR: 2.49, 95% CI: 2.04\u20133.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), which persisted after adjusting for age, sex, body mass index, coronary artery disease, HF, renal function, and left ventricular ejection fraction. The association with VA was stronger in secondary versus primary prevention ICD indication: HR: 1.59 (95% CI: 1.34\u20131.88 C\u2010statistics 0.71) versus HR: 1.24, 95% CI: 1.02\u20131.51, C\u2010statistics 0.55),\n                      <jats:italic>p<\/jats:italic>\n                      \u2010for\u2010interaction\u2009=\u20090.06. Changes in NT\u2010proBNP during the first 1.4 years did not associate with subsequent VA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NT\u2010proBNP concentrations are associated with the risk of incident VA after adjustment for established risk factors, with the strongest association in patients with a secondary prevention ICD indication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.24074","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:41:56Z","timestamp":1688431316000},"page":"989-996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["N\u2010terminal pro\u2010B\u2010type natriuretic peptide for prediction of ventricular arrhythmias: Data from the SMASH study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1068-8753","authenticated-orcid":false,"given":"N.","family":"Sourour","sequence":"first","affiliation":[{"name":"Department of Cardiology, Division of Medicine Akershus University Hospital L\u00f8renskog Norway"},{"name":"K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Riveland","sequence":"additional","affiliation":[{"name":"Department of Cardiology Stavanger University Hospital Stavanger Norway"},{"name":"Institute of Clinical Sciences University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"N\u00e6sgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Stavanger University Hospital Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kjekshus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Medicine Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. I.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Stavanger University Hospital Stavanger Norway"},{"name":"Institute of Clinical Sciences University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Omland","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Medicine Akershus University Hospital L\u00f8renskog Norway"},{"name":"K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"R\u00f8sj\u00f8","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine Oslo Norway"},{"name":"Division for Research and Innovation Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. L.","family":"Myhre","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Medicine Akershus University Hospital L\u00f8renskog Norway"},{"name":"K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaed\/mkv056"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61413-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1474651409344927"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.07.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.12.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp123"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.10.038"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.09.048"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-317701"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.04.024"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12985"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.12.032"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.025"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000144310.04433.BE"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031994"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.069"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.05.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eul082"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(95)00082-8"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.3.1094"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.3.968"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.832576"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.058198"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.076117"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.03.074"},{"issue":"41","key":"e_1_2_9_29_1","first-page":"2793","article-title":"Developed by the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC) endorsed by the Association for European Paediatric and Congenital Cardiology (AEPC)","volume":"36","author":"2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","year":"2022","journal-title":"Eur Heart J"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90474-F"},{"key":"e_1_2_9_30_2","unstructured":"Discussion38D\u201039D."},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.5.1724"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.24074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T01:52:04Z","timestamp":1692669124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.24074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,3]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/clc.24074"],"URL":"https:\/\/doi.org\/10.1002\/clc.24074","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,3]]},"assertion":[{"value":"2022-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}