{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:37:56Z","timestamp":1791005876264,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac dysfunction is a serious complication of cirrhosis which is usually asymptomatic. We investigated the clinical and electrocardiographic (ECG)\u2010related factors among patients with cirrhosis and our aim was to find any associations between ECG changes and the etiology of cirrhosis, as well as Child\u2010Pugh score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that some ECG\u2010related factors, particularly prolonged QT interval, are more common in patients with cirrhosis. Also, these factors are associated with the severity of cirrhosis, measured by the Child\u2010Pugh score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From April 2019 to December 2022, we reviewed admitted patients to Namazi and Abu\u2010Ali Sina hospitals, Shiraz, Iran. Patients with confirmed diagnosis of cirrhosis and without concurrent disorders affecting the cardiovascular system were selected. Clinical and ECG\u2010related data were then extracted for participants, and Child\u2010Pugh score was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 425 patients were included; the median age was 36 years, and 245 patients (57.6%) were men. Cryptogenic and primary sclerosing cholangitis were the most common etiologies. Prolonged QT followed by early transitional zone were the most common ECG changes (24.7% and 19.8%, respectively), which were significantly associated with the etiology of cirrhosis and Child\u2010Pugh class.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prolonged QT interval and presence of early transitional zone in patients with cirrhosis may indicate cardiac dysfunction, necessitating further evaluations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24089","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T15:54:00Z","timestamp":1689177240000},"page":"967-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Electrocardiographic characteristics of cirrhotic patients and their association with Child\u2010Pugh score"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-9043","authenticated-orcid":false,"given":"Soodeh","family":"Jahangiri","sequence":"first","affiliation":[{"name":"Endocrine Research Center, Institute of Endocrinology and Metabolism Iran University of Medical Sciences Tehran Iran"},{"name":"Cardiovascular Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Abdiardekani","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Department of Cardiology, Abu\u2010Ali Sina Charity Hospital Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saideh","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Askarinejad","sequence":"additional","affiliation":[{"name":"Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SeyedArad","family":"Mosalamiaghili","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Bazrafshan","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamadreza","family":"Karimi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shiraz University of Medical Sciences Shiraz 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