{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:32:58Z","timestamp":1790415178106,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Catheter ablation (CA) combined with left atrial appendage occlusion (LAAO) is a feasible approach for atrial fibrillation (AF) patients. Its role in octogenarians with AF is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>In AF patients over 80 years, CA combined with LAAO is a feasible way in restoring sinus rhythm and preventing stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a single\u2010center retrospective study. Patients who underwent CA and LAAO in a single procedure between March 2018 and December 2020 were included. Efficacy endpoints included procedural success rate, AF recurrence rate, and thromboembolic events. Safety endpoints included pericardial effusion\/cardiac tamponade, device\u2010related thrombus (DRT), all\u2010cause death, and major bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred and five patients (mean age 69.5\u2009\u00b1\u20097.7 years; 230 [45.5%] female) were included, with 46 (9.1%) patients aged \u226580 years old (octogenarian group). Prevalence of paroxysmal AF (25 [54.3%] vs. 207 [45.1%], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and CHA2DS2VASc score (4.1\u2009\u00b1\u20091.3 vs. 3.1\u2009\u00b1\u20091.4, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) were higher in octogenarian patients. There were six cases (1.2%) of pericardial effusion (all in nonoctogenarian patients). At 3 months postprocedure, 437 patients underwent TEE\/CT. Thirty\u2010two (80%) octogenarian patients and 308 (77.6%) nonoctogenarian patients had no peri\u2010device leak. After a mean follow\u2010up of 26.9\u2009\u00b1\u20099.1 months, AF was documented in 10 (21.7%) patients in octogenarian group and in 103 (22.4%) patients in nonoctogenarian group (<jats:italic>p<\/jats:italic>\u2009=\u20090.99). The annual thromboembolic risk was 2.1% and 0.8% in the octogenarian group and nonoctogenarian group, respectively. Death occurred in 16 nonoctogenarian patients. One major bleeding was recorded in the octogenarian group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of CA and LAAO in a single procedure is a feasible treatment option in octogenarians with comparable efficacy and safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24099","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T10:34:48Z","timestamp":1690799688000},"page":"1202-1209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Safety and efficacy of ablation for atrial fibrillation in combination with left atrial appendage occlusion in octogenarians"],"prefix":"10.1002","volume":"46","author":[{"given":"Peng\u2010Pai","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai 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Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin\u2010Feng","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong 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