{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:52:22Z","timestamp":1740145942437,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Health care resource utilization (HCRU) and costs are important metrics of health care burden, but they have rarely been explored in the setting of cardiac ion channelopathies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>This study tested the hypothesis that attendance\u2010related HCRUs and costs differed between patients with Brugada syndrome (BrS) and congenital long QT syndrome (LQTS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of consecutive BrS and LQTS patients at public hospitals or clinics in Hong Kong, China. HCRUs and costs (in USD) for Accident and Emergency (A&amp;E), inpatient, general outpatient and specialist outpatient attendances were analyzed between 2001 and 2019 at the cohort level. Comparisons were made using incidence rate ratios (IRRs [95% confidence intervals]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the 19\u2010year period, 516 BrS (median age of initial presentation: 51 [interquartile range: 38\u221261] years, 92% male) and 134 LQTS (median age of initial presentation: 21 [9\u221244] years, 32% male) patients were included. Compared to LQTS patients, BrS patients had lower total costs (2\u2009008\u2009126 [2\u2009007\u2009622\u22122\u2009008\u2009629] vs. 2\u2009343\u2009864 [2\u2009342\u2009828\u22122\u2009344\u2009900]; IRR: 0.857 [0.855\u22120.858]), higher costs for A&amp;E attendances (83\u2009113 [83\u2009048\u221283\u2009177] vs. 70\u2009604 [70\u2009487\u221270\u2009721]; IRR: 1.177 [1.165\u22121.189]) and general outpatient services (2,176 [2,166\u22122,187] vs. 921 [908\u2212935]; IRR: 2.363 [2.187\u22122.552]), but lower costs for inpatient stay (1\u2009391\u2009624 [1\u2009391\u2009359\u22121\u2009391\u2009889] vs. 1\u2009713\u2009742 [1\u2009713\u2009166\u22121\u2009714\u2009319]; IRR: 0.812 [0.810\u22120.814]) and lower costs for specialist outpatient services (531\u2009213 [531\u2009049\u2212531\u2009376] vs. 558\u2009597 [558268\u2212558926]; IRR: 0.951 [0.947\u22120.9550]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, BrS patients consume 14% less health care resources compared to LQTS patients in terms of attendance costs. BrS patients require more A&amp;E and general outpatient services, but less inpatient and specialist outpatient services than LQTS patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24102","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T12:49:54Z","timestamp":1690289394000},"page":"1194-1201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Secular trends of health care resource utilization and costs between Brugada syndrome and congenital long QT syndrome: A territory\u2010wide study"],"prefix":"10.1002","volume":"46","author":[{"given":"Sharen","family":"Lee","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology Unit, Cardiovascular Analytics Group PowerHealth Limited  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheuk To Skylar","family":"Chung","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology 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Analytics Group PowerHealth Limited  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7517-5548","authenticated-orcid":false,"given":"Leonardo","family":"Roever","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Federal University of Uberlandia  Uberlandia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Rajan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sabah Al Ahmed Cardiac Centre  Kuwait City Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Bazoukis","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology Evangelismos General Hospital of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos P.","family":"Letsas","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit Onassis Cardiac Surgery Center  Athens 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