{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:56:55Z","timestamp":1791907015224,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Iron deficiency (ID) is one of the most common factors that may reduce sports performance, supplementation forms and doses are still not standardized in athletes. Our aim was to assess the iron status of young male basketball players and to study the effect of iron supplementation in a randomized placebo\u2010controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that due to the higher iron demand of athletes, the 100\u2009\u03bcg\/L ferritin cut\u2010off may be appropriate to determine the non\u2010anemic ID.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During a sports cardiology screening, questionnaires, laboratory tests, electrocardiograms, echocardiography exams, and cardiopulmonary exercise tests were performed. Athletes with ID (ferritin &lt;100\u2009\u03bcg\/L) were randomized into iron and placebo groups. Ferrous sulfate (containing 100\u2009mg elemental iron [II] and 60\u2009mg ascorbic acid) or placebo (50\u2009mg vitamin C) was administered for 3 months. All exams were repeated after the supplementation period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 65 (age 15.8\u2009\u00b1\u20091.7 years) basketball players divided into four age groups. Non\u2010anemic ID was observed in 60 (92%) athletes. After supplementation, ferritin levels were higher in the iron group (75.5\u2009\u00b1\u200925.9 vs. 54.9\u2009\u00b1\u200910.4\u2009\u03bcg\/L, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Ferritin &gt;100\u2009\u03bcg\/L level was achieved only in 15% of the athletes. There were no differences in performance between the groups (VO<jats:sub>2<\/jats:sub> max: 53.6\u2009\u00b1\u20094.3 vs. 54.4\u2009\u00b1\u20095.7\u2009mL\/kg\/min, <jats:italic>p<\/jats:italic>\u2009=\u2009.46; peak lactate: 9.1\u2009\u00b1\u20092.2 vs. 9.1\u2009\u00b1\u20092.6\u2009mmol\/L, <jats:italic>p<\/jats:italic>\u2009=\u2009.90).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As a result of the 3\u2010month iron supplementation, the ferritin levels increased; however, only a small portion of the athletes achieved the target ferritin level, while performance improvement was not detectable.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24117","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T11:30:49Z","timestamp":1690543849000},"page":"1116-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Iron deficiency in young basketball players: Is a 100\u2009\u03bcg\/L ferritin cut\u2010off appropriate for iron supplementation?: Results of a randomized placebo\u2010controlled study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-8000","authenticated-orcid":false,"given":"Emese","family":"Csulak","sequence":"first","affiliation":[{"name":"Heart and Vascular Center Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titanilla","family":"Tak\u00e1cs","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-8891","authenticated-orcid":false,"given":"Brigitta","family":"Babis","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Hematology Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"M\u00e1rton","sequence":"additional","affiliation":[{"name":"Honv\u00e9d Basketball Academy  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7627-5620","authenticated-orcid":false,"given":"B\u00e1lint","family":"Lakatos","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-6434","authenticated-orcid":false,"given":"Attila","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6270-719X","authenticated-orcid":false,"given":"Levente","family":"Staub","sequence":"additional","affiliation":[{"name":"Argus Cognitive, Inc.  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