{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T18:28:59Z","timestamp":1749061739259,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070357","82200284"],"award-info":[{"award-number":["82070357","82200284"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M732406"],"award-info":[{"award-number":["2023M732406"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005024","name":"Beijing Postdoctoral Research Foundation","doi-asserted-by":"publisher","award":["2023\u2010ZZ\u2010007"],"award-info":[{"award-number":["2023\u2010ZZ\u2010007"]}],"id":[{"id":"10.13039\/501100005024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>\u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic receptor autoantibody (\u03b2<jats:sub>2<\/jats:sub>\u2010AA) are widely present in patients with many different types of cardiovascular diseases. Proximal left anterior descending (LAD) artery lesions are associated with adverse prognostic events in patients with ST\u2010segment elevation myocardial infarction (STEMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>\u03b2<jats:sub>2<\/jats:sub>\u2010AA is associated with the presence of proximal LAD lesions in patients with STEMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 153 patients with STEMI who underwent primary percutaneous coronary intervention (PPCI) was enrolled in the study. Baseline characteristics were compared between the proximal LAD group (<jats:italic>n<\/jats:italic>\u2009=\u200962) and the nonproximal LAD group (<jats:italic>n<\/jats:italic>\u2009=\u200991). Admission serum of patients was collected to detect the level of \u03b2<jats:sub>2<\/jats:sub>\u2010AA. Data for echocardiogram within 24\u2009hours after PPCI and at the 6\u2010month follow\u2010up were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The optical density values and positive rates of \u03b2<jats:sub>2<\/jats:sub>\u2010AA in the proximal LAD group were higher than those in the nonproximal LAD group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). \u03b2<jats:sub>2<\/jats:sub>\u2010AA positively correlated with high sensitivity C\u2010reactive protein and peak N\u2010terminal pro\u2010B type natriuretic peptide levels in the proximal LAD group, but those were not relevant in the nonproximal LAD group. Multivariate logistic regression analysis revealed that high \u03b2<jats:sub>2<\/jats:sub>\u2010AA levels was independently associated with the presence of proximal LAD lesions in patients with STEMI. Furthermore, a receiver operating characteristic curve was used to show the efficiency of \u03b2<jats:sub>2<\/jats:sub>\u2010AA levels to detect proximal LAD lesions, and the AUC of the \u03b22\u2010AA OD value was 0.658 (95% confidence interval 0.568\u22120.749; <jats:italic>p<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The STEMI patients with high \u03b2<jats:sub>2<\/jats:sub>\u2010AA levels had a greater possibility having proximal LAD lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24129","type":"journal-article","created":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:58:01Z","timestamp":1692568681000},"page":"1371-1379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association among \u03b22\u2010adrenergic receptor autoantibodies and proximal left anterior descending artery lesions in patients with initial ST\u2010segment elevation myocardial infarction"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3553-7556","authenticated-orcid":false,"given":"Wenxi","family":"Dang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3961-3819","authenticated-orcid":false,"given":"Ning","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease Beijing China"},{"name":"Laboratory of Clinical Medicine Capital Medical University Beijing 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5900-7088","authenticated-orcid":false,"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease Beijing China"},{"name":"Laboratory of Clinical Medicine Capital Medical University Beijing 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