{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T09:24:06Z","timestamp":1772616246316,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T00:00:00Z","timestamp":1693699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Because of the advancement of bioabsorbable polymers and thinner struts, bioabsorbable\u2010polymer sirolimus\u2010eluting stents (BP\u2010SES) with ultrathin struts may be related to superior performance when compared to durable\u2010polymer drug\u2010eluting stents (DP\u2010DES) with thin struts. Nonetheless, the long\u2010term safety of ultrathin BP\u2010SES in acute coronary syndrome (ACS) remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We sought to assess the long\u2010term safety of ultrathin BP\u2010SES in ACS patients, conducting a thorough meta\u2010analysis of all relevant trials drawing a comparison between ultrathin BP\u2010SES and contemporary thin DP\u2010DES. Target lesion failure (TLF), which includes cardiac death (CD), target\u2010vessel myocardial infarction (TV\u2010MI), and clinically driven target lesion revascularization (CD\u2010TLR) was considered the primary endpoint. Multiple databases comprising Embase, MEDLINE, Cochrane Library, and Pubmed were all thoroughly searched.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were seven randomized controlled trials included in our study with 7522 randomized patients with ACS (BP\u2010SES\u2009=\u20093888, DP\u2010DES\u2009=\u20093634). TLF occurred in 371 (9.5% in BP\u2010SES) and 393 (10.8% in DP\u2010DES) patients, respectively, across a 40.7\u2010month weighted mean follow\u2010up, with no statistically significant group differences (risk ratio [RR]: 0.87; 95% confidence interval [CI]: 0.73\u20131.04; <jats:italic>p<\/jats:italic>\u2009=\u2009.12). Furthermore, no significant differences in cardiac death (RR: 0.96; 95% CI: 0.68\u20131.35; <jats:italic>p<\/jats:italic>\u2009=\u2009.81), TV\u2010MI (RR: 0.63; 95% CI: 0.36\u20131.10; <jats:italic>p<\/jats:italic>\u2009=\u2009.10) and CD\u2010TLR (RR: 0.77; 95% CI: 0.46\u20131.29; <jats:italic>p<\/jats:italic>\u2009=\u2009.32) were detected between two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>During a follow\u2010up of 40.7 months, ultrathin BP\u2010SES and thin DP\u2010DES had a comparable risk of TLF and its individual components (CD, TV\u2010MI, and CD\u2010TLR), indicating that ultrathin BP\u2010SES held at least the same safety and efficiency as thin DP\u2010DES presented in patients with ACS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24139","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T04:49:39Z","timestamp":1693802979000},"page":"1465-1473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term safety of ultrathin bioabsorbable\u2010polymer sirolimus\u2010eluting stents versus thin durable\u2010polymer drug\u2010eluting stents in acute coronary syndrome: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5946-3018","authenticated-orcid":false,"given":"Fadong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital Capital Medical University Beijing 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