{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:49:15Z","timestamp":1791920955394,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The hybrid strategy of a combination of drug\u2010eluting stent (DES) and drug\u2010coated balloon (DCB) is promising for the treatment of de novo diffuse coronary artery disease (CAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>To investigate the efficacy and functional results of hybrid strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case series study included patients treated with a hybrid approach for de novo diffuse CAD between February 2017 and November 2021. Postprocedural quantitative flow ratio (QFR) was used to evaluate the functional results. The primary endpoint was procedural success rate. The secondary endpoints were major adverse cardiovascular events (MACE) including cardiac death, myocardial infarction (MI) (including peri\u2010procedural MI), and target vessel revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 109 patients with 114 lesions were treated. DES and DCB were commonly used in larger proximal segments and smaller distal segments, respectively. The mean QFR value was 0.9\u2009\u00b1\u20090.1 and 105 patients (96.3%) had values &gt;0.8 in all the treated vessels. Procedural success was achieved in 106 (97.2%) patients. No cases of cardiac death were reported at a median follow\u2010up of 19 months. Spontaneous MI occurred in three (2.8%) patients and target vessel revascularization in six (5.5%) patients. Estimated 2\u2010year rate of MACE excluding peri\u2010procedural MI was higher in the group with lower QFR value (12.1\u2009\u00b1\u20095.7% vs. 5.6\u2009\u00b1\u20094.4%, log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u2009.035) (cut\u2010off value 0.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hybrid strategy is a promising approach for the treatment of de novo diffuse CAD. Postprocedural QFR has some implications for prognosis and may be helpful in guiding this approach.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24140","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:43:15Z","timestamp":1693892595000},"page":"1511-1518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Drug\u2010eluting stent and drug\u2010coated balloon for the treatment of de novo diffuse coronary artery disease lesions: A retrospective case series study"],"prefix":"10.1002","volume":"46","author":[{"given":"Haobo","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences Beijing People's Republic of 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