{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T22:45:31Z","timestamp":1771022731566,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Frailty is an issue in patients with heart failure (HF). A Korean version of the frailty scale (K\u2010FRAIL) has been developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We aimed to analyze the relationship between the K\u2010FRAIL scale and physical performance in patients with HF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 142 patients with HF aged \u226565 years from a single center. Muscular fitness was assessed using the handgrip test and knee extensor strength measurement. Aerobic capacity was assessed using the cardiopulmonary exercise test and 6\u2010min walk test (6MWT). Frailty was assessed using the K\u2010FRAIL questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peak VO<jats:sub>2<\/jats:sub> and 6MWT scores significantly decreased as frailty worsened, but handgrip and knee extensor strength did not. In the multivariate analysis, peak VO<jats:sub>2<\/jats:sub> (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u2212.31; <jats:italic>p<\/jats:italic>\u2009=\u2009.002) and 6MWT score (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u2212.38; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) showed significant inverse associations with the K\u2010FRAIL score. Based on the receiver operating characteristic curve analysis, the cut\u2010off values of peak VO<jats:sub>2<\/jats:sub> (hazard ratio, 5.08; <jats:italic>p<\/jats:italic>\u2009=\u2009.023) and 6MWT (hazard ratio, 3.99; <jats:italic>p<\/jats:italic>\u2009=\u2009.020) were independent predictors of frailty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In older patients with HF, physical performance correlates with the degree of frailty. The K\u2010FRAIL scale is correlated with the peak VO<jats:sub>2<\/jats:sub> and 6MWT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24142","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T09:42:00Z","timestamp":1694079720000},"page":"1530-1537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between frailty and physical performance in older patients with heart failure"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8406-8886","authenticated-orcid":false,"given":"Uram","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Cardiology Ajou University School of Medicine Suwon\u2010si Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjae","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Cardiology Severance Cardiovascular Hospital and Cardiovascular 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