{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:44:14Z","timestamp":1792511054599,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Living alone is an objective sign of social isolation. It is uncertain whether living alone worsens clinical outcomes in heart failure (HF) patients. We aimed to assess how living alone affected clinical outcomes in individuals with HF. We searched the electronic databases of PubMed, Embase, and Cochrane from 1990 to April 2022 for studies comparing living alone with HF. A random\u2010effects model with inverse variance was used to pool adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Seven studies were deemed to meet the standards. In patients with HF, compared with living with others, living alone was associated with an elevated risk of any hospitalization at the 30\u2010day (HR: 1.78, 95% CI: 1.09\u20132.89), 90\u2010day (HR: 1.24, 95% CI: 1.02\u20131.51), or \u22651\u2010year (HR: 1.14, 95% CI: 1.04\u20131.26) follow\u2010up periods. HF patients living alone also had a greater risk of any hospitalization or death at the 30\u2010day (HR: 1.56, 95% CI: 1.15\u20132.11), 90\u2010day (HR: 1.26, 95% CI: 1.05\u20131.50), and \u22651\u2010year (HR: 1.18, 95% CI: 1.09\u20131.28) follow\u2010up periods. However, patients living alone had no increased risk of all\u2010cause death at the 30\u2010day (HR: 1.0, 95% CI: 0.19\u20135.36), 90\u2010day (HR: 0.46, 95% CI: 0.03\u20137.42), or \u2265 1\u2010year (HR: 1.10, 95% CI: 0.73\u20131.67) follow\u2010up periods. In comparison to living with others, living alone was associated with an increased risk of any hospitalization but not all\u2010cause death in HF patients.<\/jats:p>","DOI":"10.1002\/clc.24153","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T04:44:13Z","timestamp":1695444253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of living alone with clinical outcomes in patients with heart failure: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"47","author":[{"given":"Haibo","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Jiangxi Mental Hospital Affiliated Mental Hospital of Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8262-812X","authenticated-orcid":false,"given":"Fuwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Ganzhou Hospital of Nanchang University Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Ganzhou Hospital of Nanchang University Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jiangxi Mental Hospital Affiliated Mental Hospital of Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Third People's Hospital of Ganzhou Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wengen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology the First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","first-page":"e29","article-title":"Heart disease and stroke statistics\u20142015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian D","year":"2015","journal-title":"Circulation"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.748"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.478"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030565"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000001073"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2019.07.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008069"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-313844"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745691614568352"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcz004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.07.185"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.02.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.00809"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_16_1","volume-title":"Cochrane handbook for systematic reviews of interventions. 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