{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:34:43Z","timestamp":1784874883391,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T00:00:00Z","timestamp":1695427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In aortic stenosis (AS), left ventricular hypertrophy (LVH) is the response to pressure overload and represents the substrate for a maladaptive cascade, the so\u2010called AS\u2010related cardiac damage. We hypothesized that in AS patients electrocardiogram (ECG) LVH not only predicts echocardiography LVH but also other noninvasive and invasive markers of cardiac damage and prognosis after aortic valve replacement (AVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 279 patients with severe AS undergoing ECG, echocardiography, and cardiac catheterization before AVR, the Sokolow\u2010Lyon index, the Cornell product, the Romhilt\u2010Estes score, and the Peguero\u2010Lo Presti score were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean left ventricular mass index was 109\u2009\u00b1\u200934\u2009g\/m<jats:sup>2<\/jats:sup>, and 131 (47%) patients had echocardiography LVH. The areas under the receiver operator characteristics curve (AUC) for the Sokolow\u2010Lyon index, the Cornell product, the Romhilt\u2010Estes score, and the Peguero\u2010Lo Presti score for the prediction of echocardiography LVH were 0.59, 0.70, 0.63, and 0.65. The Peguero\u2010Lo Presti score had the numerically greatest AUC for the prediction of left ventricular end\u2010diastolic pressure &gt;15\u2009mmHg, mean pulmonary artery wedge pressure &gt;15\u2009mmHg, pulmonary vascular resistance &gt;3 Wood units, mean right atrial pressure &gt;14\u2009mmHg, and stroke volume index &lt;31\u2009mL\/m<jats:sup>2<\/jats:sup>. After a median follow\u2010up of 1365 (interquartile range: 931\u20131851) days after AVR only the Peguero\u2010Lo Presti score was significantly associated with all\u2010cause mortality [hazard ratio: 1.24 (95% confidence interval: 1.01\u20131.54); per 1\u2009mV increase; <jats:italic>p<\/jats:italic>\u2009=\u2009.045].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among severe AS patients, the Peguero\u2010Lo Presti score is associated with abnormalities in cardiac structure including LVH, invasive measures of cardiac damage, and long\u2010term mortality after AVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24155","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T07:39:11Z","timestamp":1695454751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["ECG left ventricular hypertrophy in aortic stenosis: Relationship with cardiac structure, invasive hemodynamics, and long\u2010term mortality"],"prefix":"10.1002","volume":"47","author":[{"given":"Patrizia","family":"Sager","sequence":"first","affiliation":[{"name":"Department of Cardiology Kantonsspital St. Gallen St. Gallen Switzerland"},{"name":"University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rusch","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital St. Gallen St. Gallen Switzerland"},{"name":"Department of Cardiology Kantonsspital M\u00fcnsterlingen M\u00fcnsterlingen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital St. Gallen St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Breuss","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital St. Gallen St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Appert","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital St. Gallen St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital St. Gallen St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Buser","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital St. Gallen St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ammann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital St. Gallen St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Rickli","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital St. Gallen St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7036-5791","authenticated-orcid":false,"given":"Micha T.","family":"Maeder","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital St. Gallen St. Gallen Switzerland"},{"name":"University of Basel Basel 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