{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:33:43Z","timestamp":1790307223418,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>A left atrial posterior wall isolation (LAPWI) is one of the atrial fibrillation (AF) ablation strategies.<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>We hypothesized that an additional empirical LAPWI would increase the freedom from recurrent atrial arrhythmias as compared to standard AF ablation in persistent AF patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>The CORNERSTONE AF study is a prospective, randomized, multicenter study investigating patients with AF persisting for >7 days and <3 years undergoing first\u2010time AF ablation. They will be randomized to pulmonary vein isolation (PVI) or PVI\u2009+\u2009LAPWI in a 1:1 manner. Although PVI can be performed with either radiofrequency catheters or cryoballoons, only radiofrequency catheters will be permitted to achieve LAPWIs. Additional focal ablation targeting non\u2010pulmonary vein triggers will be allowed. A total of 516 patients will be enrolled in 17 centers between August 2022 and February 2024 based on the calculation with 80% power, considering the assumption that 65% and 75% of the PVI and PVI\u2009+\u2009LAPWI group patients will be free from atrial arrhythmia recurrence 18\u2010months postprocedure (10% of dropout). The primary endpoint is freedom from documented atrial arrhythmias 18 months postsingle procedures. Clinical follow\u2010up will include 7\u2010day ambulatory electrocardiograms and routine outpatient consultations by electrophysiologists at 1, 3, 6, 9, 12, and 18 months postprocedure.<\/jats:p><\/jats:sec>Results<\/jats:title>As of August 2023, a total of 331 patients (68\u2009\u00b1\u20099 years, 270 men, 43 longstanding persistent AF) have been enrolled.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The CORNERSTONE AF study is a prospective, randomized, multicenter trial designed to evaluate the efficacy and safety of an adjunctive empirical LAPWI following standard AF ablation in persistent AF patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24164","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T06:58:00Z","timestamp":1697093880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adjunctive posterior wall isolation for the treatment of persistent and longstanding persistent atrial fibrillation (CORNERSTONE AF) trial: Design and rationale"],"prefix":"10.1002","volume":"47","author":[{"given":"Takatoshi","family":"Shigeta","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0230-0934","authenticated-orcid":false,"given":"Shinsuke","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Saitama Hospital Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Inamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross 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