{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:33:44Z","timestamp":1770291224116,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:00:00Z","timestamp":1696636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Catheter ablation (CA) combined with left atrial appendage closure (LAAC) has emerged as a promising method to relieve symptoms while reducing the incidence of stroke in selected high\u2010risk patients with atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We aimed to investigate the clinical outcomes of combined CA and LAAC in elderly patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 316 patients with symptomatic drug\u2010refractory AF who underwent combined CA and LAAC between January 2016 and December 2020 were retrospectively included. Baseline characteristics, periprocedural complications, and clinical events during follow\u2010up were recorded and compared between patients aged\u2009\u2265\u200975 years (<jats:italic>n<\/jats:italic>\u2009=\u200966) and &lt;75 years (<jats:italic>n<\/jats:italic>\u2009=\u2009250).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pulmonary vein isolation and satisfactory LAAC were achieved in all patients. No patients experienced death or stroke\/transient ischemic stroke periprocedurally. After a median follow\u2010up of 12.2 (6.7\u221224.4) months and 11.9 (5.5\u221223.6) months, the rate of sinus rhythm maintenance was comparable between the two groups (\u226575 years: 78.8% vs. &lt;75 years: 80.8%; log\u2010rank test, <jats:italic>p<\/jats:italic>\u2009=\u20090.674). The median follow\u2010up periods for clinical outcomes were 27.9 (9.3\u221244.8) months and 25.2 (10.8\u221245.7) months, respectively. In patients aged \u2265 75 years, one suffered ischemic stroke, and one experienced major bleeding event. In patients aged &lt; 75 years, four had ischemic stroke, and eight had major bleeding events. Two patients aged &lt; 75 years died during follow\u2010up, while none of the patients aged \u2265 75 years died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combining CA and LAAC was feasible, safe and effective in elderly patients with AF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24169","type":"journal-article","created":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T18:45:02Z","timestamp":1696790702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical outcomes of combined catheter ablation and left atrial appendage closure in elderly patients with nonvalvular atrial fibrillation"],"prefix":"10.1002","volume":"47","author":[{"given":"Xiaohong","family":"Fei","sequence":"first","affiliation":[{"name":"Arrhythmia Center, the First Affiliated Hospital of Ningbo University Ningbo China"},{"name":"Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5341-3878","authenticated-orcid":false,"given":"Binhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, the First Affiliated Hospital of Ningbo University Ningbo China"},{"name":"Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-0708","authenticated-orcid":false,"given":"Huimin","family":"Chu","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, the First Affiliated Hospital of Ningbo University Ningbo China"},{"name":"Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohua","family":"Fu","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, the First Affiliated Hospital of Ningbo University Ningbo China"},{"name":"Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibo","family":"Yu","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, the First Affiliated Hospital of Ningbo University Ningbo China"},{"name":"Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjun","family":"Feng","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, the First Affiliated Hospital of Ningbo University Ningbo China"},{"name":"Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianfeng","family":"Du","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, the First Affiliated Hospital of Ningbo University Ningbo China"},{"name":"Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, the First Affiliated Hospital of Ningbo University Ningbo China"},{"name":"Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo Zhejiang Province 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