{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:00Z","timestamp":1753868640831,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of acute coronary syndrome (ACS) among young adults (premature ACS) has dramatically increased in recent years, especially in developing countries. Yet, the data on these patients' attributed risk factors and outcomes are inconsistent. In this study, we aimed to investigate these data in a cohort of premature ACS cases who underwent percutaneous coronary intervention (PCI) compared to older patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesize that premature ACS patients undergoing PCI will exhibit different risk factor profiles and outcomes compared to non\u2010premature patients. specifically, we anticipate that premature patients do not necessarily have better outcomes than non\u2010premature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 3142 and 10 399 patients were included in premature and non\u2010premature groups, respectively. Patients' pre\u2010operative, post\u2010operative, and follow\u2010up data were retrieved retrospectively from the Tehran Heart Center PCI databank.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of premature and non\u2010premature cohorts was 48.39 and 67 years, respectively. Patients were predominantly male in both groups. Family history of coronary artery disease (CAD), dyslipidemia, smoking, and opium addiction were more prevalent among the younger cohort. After adjustment, in\u2010hospital mortality in younger patients was considerably higher, with all\u2010cause mortality and major cardiovascular and cerebrovascular events (MACCE) exhibiting no noticeable difference among the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Risk factor profile is different in young patients, and traditional cardiovascular risk factors, such as hypertension and diabetes mellitus, are more prevalent among older adults. Younger age is not equivalent to a better prognosis; hence, similar or even more caution should be taken into consideration regarding secondary prevention for these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24170","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T05:33:04Z","timestamp":1697088784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk factor profile and outcomes of premature acute coronary syndrome after percutaneous coronary intervention: A 1\u2010year prospective design"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-0980","authenticated-orcid":false,"given":"Aida","family":"Fallahzadeh","sequence":"first","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Disease Research Institute Tehran University of Medical Sciences Tehran 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