{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:21:27Z","timestamp":1790277687689,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:00:00Z","timestamp":1703462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170453"],"award-info":[{"award-number":["82170453"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The present study aimed to examine the correlation between serum cytokine levels and the incidence of coronary artery disease (CAD), a leading cause of mortality globally, which is known to have a strong association with inflammatory factors. The study further sought to determine the predictors of CAD to distinguish patients with coronary artery lesions from those suspected of having CAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>In this study, 487 patients who underwent coronary angiography as a result of suspected CAD but without acute myocardial infarction (AMI) were recruited. The serum levels of the cytokines interleukin (IL)\u20101\u03b2, IL\u20102, IL\u20104, IL\u20105, IL\u20106, IL\u20108, IL\u201010, IL\u201012p70, IL\u201017, tumor necrosis factor\u2010\u03b1, interferon (IFN)\u2010\u03b1, and IFN\u2010\u03b3 were measured using a multiplexed particle\u2010based flow cytometric assay technique. The results of the study revealed that the levels of IL\u20104, IL\u201012p70, IL\u201017, IFN\u2010\u03b1, and IFN\u2010\u03b3 in the CAD group were significantly lower compared to those in the non\u2010CAD group. Multivariate logistic regression analysis indicated that two serum cytokines (IL\u20104 and IL\u201017), one protective factor (high\u2010density lipoprotein cholesterol [HDL\u2010C]), and three risk factors (sex, smoking, and diabetes) were independently predictive of CAD. The receiver operating characteristic curve analysis showed that the combined use of these predictors in a multivariate model demonstrated good predictive performance for CAD, as evidenced by an area under the curve value of 0.826.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of the study indicated that serum IL\u20104 and IL\u201017 levels serve as independent predictors of CAD. The risk prediction model established in the research, which integrates these serum cytokines (IL\u20104 and IL\u201017) with relevant clinical risk factors (gender, smoking, and diabetes) and the protective factor HDL\u2010C, holds the potential to differentiate patients with CAD from those suspected of having CAD but without AMI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24188","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T06:09:57Z","timestamp":1703570997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Interleukin\u20104 and Interleukin\u201017 are associated with coronary artery disease"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9288-1340","authenticated-orcid":false,"given":"Chenyang","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Coronary Heart Disease, Beijing Anzhen Hospital Capital Medical 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