{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:46Z","timestamp":1786977406084,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early detection of coronary atherosclerotic diseases (CAD) without regional wall motion abnormality (RWMA) is important for improving the outcome of cardiovascular events. Global myocardial work (GMW), including global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW), and global myocardial work efficiency (GWE), offer comprehensive quantitative assessment of myocardial function in CAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>We hypothesized that GMW could provide incremental value in detecting CAD without RWMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and twenty\u2010four patients referred for coronary angiography (CAG) without resting RWMA were enrolled in this study. Global longitudinal strain (GLS), GWI, GCW, GWW, GWE were quantified. The severity of coronary lesions was evaluated by Gensini score (GS) based on CAG. We further divided CAG\u2010confirmed CAD patients into three subgroups according to the tertiles of GS: low 0\u2009&lt;\u2009GS\u2009\u2264\u200917, mid 17\u2009&lt;\u2009GS\u2009\u2264\u200938, and high GS\u2009&gt;\u200938.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with control, CAD patients showed decreased GLS, GWE, GWI, GCW but an increased GWW. Compared to low\u2010GS group, GWW was increased in the mid\u2010GS group. GLS, GWE, GWI and GCW were decreased in the high\u2010GS group while GWW was increased. Receiver operator characteristic curve analysis demonstrated that GWE was the most powerful predictor of high\u2010GS and was superior to GLS. GWE under 92.0% had the optimal sensitivity and specificity for identifying high\u2010GS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proposed GWE, which outperformed the conventional GLS, could be considered as a potential predictive indicator to help to detect severe coronary disease in non\u2010RWMA CAD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.24193","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T09:53:50Z","timestamp":1701165230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Global myocardial work in coronary artery disease patients without regional wall motion abnormality: Correlation with Gensini\u2010score"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4360-1960","authenticated-orcid":false,"given":"Miao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Ultrasound, Nanjing First Hospital Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound, Nanjing First Hospital Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound, Nanjing First Hospital Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound, Nanjing First Hospital Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, No. 905 Hospital of People's Liberation Army Navy Naval Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound, Nanjing First Hospital Nanjing Medical University Nanjing 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