{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:09:02Z","timestamp":1783984142142,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004817","name":"Lund University Medical Faculty Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Noninvasive left ventricular (LV) pressure\u2010volume (PV) loops derived by cardiac magnetic resonance (CMR) have recently been shown to enable characterization of cardiac hemodynamics. Thus, such PV loops could potentially provide additional diagnostic information such as contractility, arterial elastance (E<jats:sub>a<\/jats:sub>) and stroke work (SW) currently not available in clinical routine. This study sought to investigate to what extent PV\u2010loop variables derived with a novel noninvasive method can provide incremental physiological information over cardiac dimensions and blood pressure in patients with acute myocardial infarction (MI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 100 patients with acute MI and 75 controls were included in the study. All patients underwent CMR 2\u22126 days after MI including assessment of myocardium at risk (MaR) and infarct size (IS). Noninvasive PV loops were generated from CMR derived LV volumes and brachial blood pressure measurements. The following variables were quantified: Maximal elastance (E<jats:sub>max<\/jats:sub>) reflecting contractility, E<jats:sub>a<\/jats:sub>, ventriculoarterial coupling (E<jats:sub>a<\/jats:sub>\/E<jats:sub>max<\/jats:sub>), SW, potential energy, external power, energy per ejected volume, and efficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All PV\u2010loop variables were significantly different in MI patients compared to healthy volunteers, including contractility (E<jats:sub>max<\/jats:sub>: 1.34\u2009\u00b1\u20090.48 versus 1.50\u2009\u00b1\u20090.41\u2009mmHg\/mL, <jats:italic>p<\/jats:italic>\u2009=\u2009.024), ventriculoarterial coupling (E<jats:sub>a<\/jats:sub>\/E<jats:sub>max<\/jats:sub>: 1.27\u2009\u00b1\u20090.61 versus 0.73\u2009\u00b1\u20090.17, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and SW (0.96\u2009\u00b1\u20090.32 versus 1.38\u2009\u00b1\u20090.32\u2009J, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). These variables correlated to both MaR and IS (E<jats:sub>max<\/jats:sub>: <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.25 and <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.29; E<jats:sub>a<\/jats:sub>\/E<jats:sub>max<\/jats:sub>: <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.36 and <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.41; SW: <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.21 and <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.25).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Noninvasive PV\u2010loops provide physiological information beyond conventional diagnostic variables, such as ejection fraction, early after MI, including measures of contractility, ventriculoarterial coupling, and SW.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24216","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:43:36Z","timestamp":1705409016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Contractility, ventriculoarterial coupling, and stroke work after acute myocardial infarction using CMR\u2010derived pressure\u2010volume loop data"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6567-8459","authenticated-orcid":false,"given":"David","family":"Nordlund","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund, Clinical Physiology Lund University and Skane University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodor","family":"Lav","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Clinical Physiology Lund University and Skane University 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