{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T12:04:17Z","timestamp":1770465857536,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiofrequency ablation has been applied for the treatment of hypertrophic obstructive cardiomyopathy (HOCM). The two known procedures are percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) and endocardial radiofrequency septal ablation (ERSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study presents a retrospective analysis of the PIMSRA and ERSA procedures in patients with drug\u2010refractory HOCM. A total of 28 patients participated in the study, with 12 receiving PIMSRA and 16 receiving ERSA. The objective of our study was to compare the short\u2010term effects of these two radiofrequency ablation procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the 30\u2010day follow\u2010up, the PIMSRA group demonstrated a greater reduction in left ventricular outflow tract peak gradient at rest compared to the ERSA group (22.25 [16.72]\u2009mmHg versus 47.75 [21.94]\u2009mmHg) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). The values for the PIMSRA group decreased from 99.33 (32.00)\u2009mmHg to 22.25 (16.72)\u2009mmHg (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), while the ERSA group decreased from 97.75 (30.24)\u2009mmHg to 47.75 (21.94)\u2009mmHg (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Only the PIMSRA group exhibited a decrease in mitral regurgitation (MR). The area of MR decreased from 10.13 (4.12)\u2009mm<jats:sup>2<\/jats:sup> to 3.65 (2.80)\u2009mm<jats:sup>2<\/jats:sup> in the PIMSRA group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Additionally, the PIMSRA group experienced reductions in left atrial diameter (LAD) and left ventricular ejection fraction (LVEF)%. The values for LAD changed from 43.58 (7.53)\u2009mm to 37.08 (6.92)\u2009mm (<jats:italic>p<\/jats:italic>\u2009=\u2009.03), and the values for LVEF% decreased from 65.75 (6.12)\u2009pg\/mL to 60.83 (4.06)\u2009pg\/mL (<jats:italic>p<\/jats:italic>\u2009=\u2009.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In terms of the two types of radiofrequency ablation methods used in HOCM, it has been observed that PIMSRA demonstrates a more favorable early treatment effect compared to ERSA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24217","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T06:46:48Z","timestamp":1709621208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Short time effects of two radiofrequency ablation methods on hypertrophic obstructive 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