{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:07:04Z","timestamp":1783544824881,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>After acute coronary syndrome (ACS), inflammation aids healing but may harm the heart. Interleukin (IL)\u201018 and IL\u20101\u03b2 are pivotal proinflammatory cytokines released during pyroptosis, a process that initiates and sustains inflammation. This study aimed to evaluate the levels of circulating IL\u201018 and IL\u20101\u03b2 during the progression of ACS and to determine their association with subsequent clinical events in ACS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Circulating levels of IL\u201018 and IL\u20101\u03b2 are associated with subsequent clinical events in ACS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Employing immunoassays, we examined plasma levels of IL\u20101\u03b2 and IL\u201018 in 159 ACS patients and matched them with 159 healthy controls. The primary composite endpoint included recurrent unstable angina, myocardial infarction, heart failure exacerbation, stroke, or cardiovascular death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ACS patients exhibited a significant increase in plasma IL\u201018 levels, measuring 6.36 [4.46\u22129.88]\u2009\u00d7\u200910<jats:sup>2<\/jats:sup>\u2009pg\/mL, in contrast to the control group with levels at 4.04 [3.21\u22124.94]\u2009\u00d7\u200910<jats:sup>2<\/jats:sup>\u2009pg\/mL (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Conversely, plasma levels of IL\u20101\u03b2 remained unchanged compared to the control group. Following a 25\u2010month follow\u2010up, IL\u201018 levels exceeding the median remained an important prognostic factor for adverse clinical events in ACS patients (hazard ratio\u2009=\u20092.37, 95% confidence interval: 1.14\u22124.91, <jats:italic>p<\/jats:italic>\u2009=\u20090.021). Besides, IL\u201018 displayed a nonlinear association with adverse clinical events (<jats:italic>p<\/jats:italic> nonlinear\u2009=\u20090.044). Subgroup analysis revealed that the correlation between IL\u201018 and the risk of adverse clinical events was not significantly affected by factors such as age, sex, history of diabetes, smoking, Gensini score, or ACS type (all <jats:italic>p<\/jats:italic> interaction &gt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IL\u201018 appears to hold potential as a predictive marker for anticipating clinical outcomes in patients with ACS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24229","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T11:28:50Z","timestamp":1706527730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prognostic significance of IL\u201018 in acute coronary syndrome patients"],"prefix":"10.1002","volume":"47","author":[{"given":"Chenchun","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Cardiology, School of Medicine, Zhongshan Hospital of Xiamen University Xiamen University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoting","family":"Yu","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, Zhongshan Hospital of Xiamen University Xiamen University Xiamen Fujian China"},{"name":"Shengli Clinical Medical College Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[{"name":"Hospital of Guizhou Medical University  Guiyang Guizhou 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