{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:07Z","timestamp":1786977487829,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T00:00:00Z","timestamp":1708819200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The ratio of nonhigh\u2010density lipoprotein\u00a0cholesterol (non\u2010HDL\u2010C) to high\u2010density lipoprotein\u00a0cholesterol (HDL\u2010C) has been shown associated with various metabolic diseases and atherosclerosis in primary prevention. However, there is limited evidence on the relationship between the non\u2010HDL\u2010C\/HDL\u2010C ratio and progression of nonculprit coronary lesion (NCCL) after percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Our study aimed to investigate the potential association between the non\u2010HDL\u2010C\/HDL\u2010C ratio and NCCL progression in patients with acute coronary syndrome (ACS) undergoing PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of ACS patients who underwent coronary angiography twice at a single center from 2016 to 2022. Lipid measurements, demographic, clinical, and other laboratory data were collected from electronic medical records. NCCLs were evaluated using quantitative coronary angiography.\u00a0The primary outcome was the progression of NCCL. Patients were categorized based on NCCL progression and tertiles of the non\u2010HDL\u2010C\/HDL\u2010C ratio. Associations were analyzed using univariate and multivariate logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 329 ACS patients who underwent PCI, with a median follow\u2010up angiography of 1.09 years. We found NCCL progression in 95 (28.9%) patients with acceptable\u00a0low\u2010density lipoprotein cholesterol control (median: 1.81\u2009mmol\/L). Patients in the top tertile of the non\u2010HDL\u2010C\/HDL\u2010C ratio had a higher risk of NCCL progression. After adjusting for potential confounding factors, the non\u2010HDL\u2010C\/HDL\u2010C ratio remained a significant predictor for NCCL progression (adjusted odds ratio: 1.45; 95% confidence interval: 1.14\u20131.86;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The non\u2010HDL\u2010C\/HDL\u2010C ratio predicts NCCL progression in ACS patients following PCI, providing a valuable tool for risk assessment and enhancing secondary prevention of atherosclerotic cardiovascular disease.<\/jats:p>\n                  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