{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:47:03Z","timestamp":1764175623898,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rate control is the most commonly employed first\u2010line management strategy for atrial fibrillation (AF) in patients with chronic kidney disease (CKD). Principal agents used to control heart rate (HR) include beta\u2010blockers (BB) and nondihydropyridine calcium channel blockers (ND\u2010CCB). However, there is a paucity of published studies of the differences between those drugs in CKD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The present study aimed to investigate the differences, in terms of hospitalizations due to a poor HR control, in patients with AF under a rate\u2010control strategy according to glomerular filtration rate (GFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study cohort included 2804 AF patients under rate\u2010control regime (BB or ND\u2010CCB) between January 2014 and April 2020. The end point, determined by competing risk regression, was hospitalizations for AF with rapid ventricular response (RVR), slow ventricular response (SVR), and need for pacemaker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On multivariate analysis, there were no statistical differences between ND\u2010CCB and BB for subjects with GFR\u2009&gt;\u200960\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> (subdistribution heart rate [sHR] 0.850, 95% confidence interval [CI]: 0.61\u20131.19; <jats:italic>p<\/jats:italic>\u2009=\u2009.442) and GFR 30\u201359\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> (sHR 1.242, 95% CI: 0.80\u20131.63; <jats:italic>p<\/jats:italic>\u2009=\u2009.333), while in patients with GFR\u2009&lt;\u200930\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>, ND\u2010CCB therapy was associated with increased hospitalizations due to poor HR control (sHR 4.53, 95% CI: 1.19\u201317.18; <jats:italic>p<\/jats:italic>\u2009=\u2009.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with GFR\u2009\u2265\u200930\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>, the choice of ND\u2010CCB or BB had no impact on hospitalizations due to poor HR control, while in GFR\u2009&lt;\u200930\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>, a possible association was detected. The effects of these drugs on GFR\u2009&lt;\u200930\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> would require further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24257","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T05:38:51Z","timestamp":1714109931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison between beta\u2010blockers and calcium channel blockers in patients with atrial fibrillation according to renal function"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1817-9697","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Parada Barcia","sequence":"first","affiliation":[{"name":"Cardiology Department University Hospital Alvaro Cunqueiro  Vigo Spain"},{"name":"University of Santiago de Compostela  Santiago 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Iglesias","family":"Otero","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital Alvaro Cunqueiro  Vigo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Gonz\u00e1lez Berm\u00fadez","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital Alvaro Cunqueiro  Vigo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"\u00cd\u00f1iguez Romo","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital Alvaro Cunqueiro  Vigo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad","family":"Abu\u2010Assi","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital Alvaro Cunqueiro  Vigo Spain"},{"name":"Health Research Institute Galicia Sur  Vigo 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