{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:06Z","timestamp":1753868646943,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We analyzed the influence of the QRS duration (QRSd) to LV end\u2010diastolic volume (LVEDV) ratio on cardiac resynchronization therapy (CRT) outcomes in heart failure patients classified as III\/IV per the New York Heart Association (NYHA) and with small body size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We proposed the hypothesis that the QRSd\/LV size ratio is a better index of the CRT substrate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 114 patients with advanced heart failure (NYHA class III\/IV, and LV ejection fraction &gt;35%) who received a CRT device, including those with left bundle branch block (LBBB) and QRSd \u2265120\u2009milliseconds (<jats:italic>n<\/jats:italic>\u2009=\u200960), non\u2010LBBB and QRSd \u2265150\u2009milliseconds (<jats:italic>n<\/jats:italic>\u2009=\u200930) and non\u2010LBBB and QRSd of 120\u2212149\u2009milliseconds (<jats:italic>n<\/jats:italic>\u2009=\u200924).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a mean follow\u2010up period of 65\u2009\u00b1\u200958 months, the incidence of the primary endpoint, a composite of all\u2010cause death and hospitalization for heart failure, showed no significant intergroup difference (43.3% vs. 50.0% vs. 37.5%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u2009.72). Similarly, among 104 patients with QRSd\/LVEDV\u2009\u2265\u20090.67 (<jats:italic>n<\/jats:italic>\u2009=\u200954) and QRSd\/LVEDV\u2009&lt;\u20090.67 (<jats:italic>n<\/jats:italic>\u2009=\u200952), no significant differences were observed in the incidence of the primary endpoint (35.1% vs. 51.9%, <jats:italic>p<\/jats:italic>\u2009=\u2009.49). Nevertheless, patients with QRSd\/LVEDV\u2009\u2265\u20090.67 showed better survival than those with QRSd\/LVEDV\u2009&lt;\u20090.67 (14.8% vs. 34.6%, <jats:italic>p<\/jats:italic>\u2009=\u2009.0024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Advanced HF patients with a higher QRSd\/LVEDV ratio showed better survival in this small\u2010body\u2013size population. Thus, the risk is concentrated among those with a larger QRSd, and patients with a relatively smaller left ventricular size appeared to benefit from CRT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24267","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T10:22:08Z","timestamp":1713176528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interaction of left ventricular size with the outcome of cardiac resynchronization therapy in Japanese patients"],"prefix":"10.1002","volume":"47","author":[{"given":"Ryo","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4985-6929","authenticated-orcid":false,"given":"Yusuke","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Advanced Cardiorhythm Therapeutics Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatsugu","family":"Kajiyama","sequence":"additional","affiliation":[{"name":"Department of Advanced Cardiorhythm Therapeutics Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyo","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba 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