{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:27:17Z","timestamp":1792592837464,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous study has demonstrated a link between TFQI, indicating the central sensitivity of thyroid hormones, and conditions like obesity, diabetes, and metabolic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Nevertheless, the potential relationship between TFQI and cardiovascular disease (CVD) in individuals with normal thyroid function has yet to be established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present research is a retrospective cohort investigation that included a total of 6297 individuals who had normal function of the thyroid and no history of thyroid disorders. These participants were selected from National Health and Nutrition Examination Survey data set, covering the years 2007\u20132012. The calculation of TFQI was performed depending on FT4 and TSH. Given the complex survey design and sample weights, we used multivariate linear regression models and stratified analysis to evaluate TFQI's correlation with CVD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjects with CVD had greater levels of TFQI than those with no CVD. After adjusting for other covariates, TFQI exhibited a positive association with CVD risk, and the OR was 1.706 (<jats:italic>p<\/jats:italic>\u2009=\u2009.005). In subgroup analyses that were stratified by sex and BMI, it was shown that female individuals who had CVD had greater levels of TFQI in comparison to female participants without CVD (<jats:italic>p<\/jats:italic>\u2009=\u2009.002). Furthermore, elevated levels of TFQI were consistently connected to a raised incidence of CVD in the BMI (&gt;28\u2009kg\/m<jats:sup>2<\/jats:sup>) group after regulating for different covariates. Furthermore, correlation analysis showed an association between TFQI and metabolic biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The levels of TFQI are strongly connected to the prevalence of CVD, indicating that energy metabolism may be related to the occurrence of CVD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24271","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T06:50:00Z","timestamp":1714373400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Relationship between Thyroid Feedback Quantile\u2010based Index and cardiovascular diseases in a population with normal thyroid function: Evidence from the National Health and Nutrition Examination Survey 2007\u20132012"],"prefix":"10.1002","volume":"47","author":[{"given":"Hui","family":"Li","sequence":"first","affiliation":[{"name":"Jinan University, Guangdong Guangzhou China"},{"name":"Department of Cardiology The First Affiliated Hospital of Bengbu Medical College Bengbu Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College Of Medicine Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College Of Medicine Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7560-295X","authenticated-orcid":false,"given":"Qingqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Bengbu Medical College Bengbu Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001052"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.964822"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1410"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.045"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.895843"},{"issue":"11","key":"e_1_2_10_7_1","first-page":"411","article-title":"A sz\u00edv\u2010 \u00e9s \u00e9rrendszeri betegs\u00e9gek \u00e9s a pszichoszoci\u00e1lis t\u00e9nyez\u0151k kapcsolata, valamint a beavatkoz\u00e1s lehet\u0151s\u00e9gei","volume":"164","author":"Cser\u00e9p Z","year":"2023","journal-title":"Orv Hetil [Associations between cardiovascular diseases and psychosocial factors and options for intervention]"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01590-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0266"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1132543"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00225-9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2011.573501"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1718-6283"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.708216"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11216530"},{"key":"e_1_2_10_16_1","first-page":"1","article-title":"The National health and nutrition examination survey: sample design, 1999\u20102006","volume":"155","author":"Curtin LR","year":"2012","journal-title":"Vital Health Stat 2"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2020.10.011"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1021326"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1159407"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-022-03279-2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.657114"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6663553"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020359"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.08.005"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.143"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.12.056"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(78)90137-3"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2304"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.06.005"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu056"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1098"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1803"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac523"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2098972"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0875"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0237-z"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.24271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T09:10:45Z","timestamp":1718010645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.24271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,28]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/clc.24271"],"URL":"https:\/\/doi.org\/10.1002\/clc.24271","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,28]]},"assertion":[{"value":"2024-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24271"}}