{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:09:11Z","timestamp":1788628151876,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Paravalvular leak (PVL) is an uncommon complication of prosthetic valve implantation, which can lead to infective endocarditis, heart failure, and hemolytic anemia. Surgical reintervention of PVLs is associated with high mortality rates.\u00a0Transcatheter PVL closure (TPVLc) has emerged as an alternative to surgical reoperation. This method provides a high success rate with a low rate of complications.\u00a0This article reviews the pathogenesis, clinical manifestation, diagnosis, and management of PVL\u00a0and complications following TPVLc. Besides, we presented a case of a patient with severe PVL following mitral valve replacement,\u00a0who experienced complete heart block (CHB) during TPVLc.\u00a0The first TPVLc procedure failed in our patient due to possible AV\u2010node insult during catheterization. After 1 week of persistent CHB, a permanent pacemaker was implanted. The defect was successfully passed using the previous attempt.\u00a0Considering the advantages of TPVLc, procedure failure should be regarded as a concern. TPVLc should be performed by experienced medical teams in carefully selected patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24272","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T11:44:31Z","timestamp":1715687071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Complications of transcatheter paravalvular leak device closure of mitral valve: An updated review of the literature and a rare case presentation"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8291-8637","authenticated-orcid":false,"given":"Yaser","family":"Jenab","sequence":"first","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Nourian","sequence":"additional","affiliation":[{"name":"Firoozgar Clinical 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