{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:27:06Z","timestamp":1782552426726,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated serum uric acid (sUA) is associated with heart failure (HF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Urate\u2010lowering therapy (ULT) in HF is associated with lower risk of HF hospitalization (hHF) and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on patients with HF and gout or hyperuricemia in the Clinical Practice Research Datalink database linked to the Hospital Episode Statistics and the Office for National Statistics in the United Kingdom were analyzed. Risks of hHF and all\u2010cause mortality or cardiovascular\u2010related mortality by ULT exposure (ULT initiated within \u22646 months of gout or hyperuricemia diagnosis) were analyzed in a propensity score\u2010matched cohort using adjusted Cox proportional hazards regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2174 propensity score\u2010matched pairs, patients were predominantly male, aged &gt;70 years, with mean\u2009\u00b1\u2009standard deviation sUA 9.3\u2009\u00b1\u20091.8 (ULT\u2010exposed) and 9.4\u2009\u00b1\u20091.9\u2009mg\/dL (ULT\u2010unexposed). At 5 years, ULT\u2010exposed patients had a 43% lower risk of hHF or all\u2010cause mortality (adjusted hazard ratio [HR]: 0.57; 95% confidence interval [CI]: 0.51\u20130.65) and a 19% lower risk of hHF or cardiovascular\u2010related mortality (adjusted HR: 0.81; 95% CI: 0.71\u20130.92) versus no ULT exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ULT was associated with reduced risk of adverse clinical outcomes in patients with HF and gout or hyperuricemia over 5 years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24297","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T09:58:10Z","timestamp":1718359090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Urate\u2010lowering therapy in patients with hyperuricemia and heart failure: A retrospective cohort study using the UK Clinical Practice Research Datalink"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4350-7437","authenticated-orcid":false,"given":"Steven J.","family":"Kiddle","sequence":"first","affiliation":[{"name":"Data Science &amp; Advanced Analytics Data Science &amp; Artificial Intelligence, R&amp;D, AstraZeneca Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina Andersson","family":"Sundell","sequence":"additional","affiliation":[{"name":"Cardiovascular, Renal and Metabolic (CVRM) Evidence, BioPharmaceuticals Medical, AstraZeneca Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Perl","sequence":"additional","affiliation":[{"name":"Late\u2010stage Development, Clinical, Cardiovascular, Renal and Metabolic (CVRM), BioPharmaceuticals R&amp;D, AstraZeneca Gaithersburg Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Nolan","sequence":"additional","affiliation":[{"name":"Late\u2010stage Development, Clinical, Cardiovascular, Renal and Metabolic (CVRM), BioPharmaceuticals R&amp;D, AstraZeneca Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Bjursell","sequence":"additional","affiliation":[{"name":"Global Medical Affairs, Clinical, Cardiovascular, Renal and Metabolic (CVRM), BioPharmaceuticals Medical, AstraZeneca Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-317833"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205953"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.06.057"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13210"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00533.2015"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv098"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0442-4"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205269"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22469"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.151199"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2014.03.2741"},{"key":"e_1_2_11_14_1","unstructured":"National Institute for Health and Care Excellence: Allopurinol Prescribing Information. 2022. 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