{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:17:31Z","timestamp":1780449451671,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In patients with transthyretin cardiac amyloidosis (ATTR\u2010CA), renal dysfunction is a poor prognostic indicator. Limited data are available on variables that portend worsening renal function (wRF) among ATTR\u2010CA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study assesses which characteristics place patients at higher risk for the development of wRF (defined as a drop of \u226510% in glomerular filtration rate [GFR]) within the first year following diagnosis of ATTR\u2010CA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included patients with ATTR\u2010CA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009134) evaluated between 2\/2016 and 12\/2022 and followed for up to 1 year at our amyloid clinic. Patients were stratified into two groups: a group with maintained renal function (mRF) and a group with wRF and compared using appropriate testing. Significant variables in the univariate analysis were included in the multivariable logistic regression model to determine characteristics associated with wRF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Within a follow\u2010up period of 326\u2009\u00b1\u2009118 days, the median GFR% change measured \u22126% [\u221218%, +8]. About 41.8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956) had wRF, while the remainder had mRF. In addition, in patients with no prior history of chronic kidney disease (CKD), 25.5% developed de novo CKD. On multivariable logistic regression, only New York Heart Association (NYHA) class \u2265III (odds ratio [OR]: 3.9, 95% confidence interval [CI]: [1.6\u20139.3]), history of ischemic heart disease (IHD) (OR: 0.3, 95% CI: [0.1\u20130.7]), and not receiving SGLT\u20102i (OR: 0.1, 95% CI: [0.02\u20130.5]) were significant predictors of wRF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrated that the development of de novo renal dysfunction or wRF is common following the diagnosis of ATTR\u2010CA. Additionally, we identified worse NYHA class and no prior history of IHD as significant predictors associated with developing wRF, while receiving SGLT\u20102i therapy appeared to be protective in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.24298","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:51:26Z","timestamp":1718344286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Predictors of developing renal dysfunction following diagnosis of transthyretin cardiac amyloidosis"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6267-8114","authenticated-orcid":false,"given":"Malcolm L.","family":"McDonald","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Disease, Heart, Vascular, and Thoracic Institute Cleveland Clinic Florida Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosef","family":"Manla","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart, Vascular, and Thoracic Institute Cleveland Clinic Abu Dhabi Abu Dhabi United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Sonnino","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Heart, Vascular, and Thoracic Institute Cleveland Clinic Florida Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mileydis","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Heart, Vascular, and Thoracic Institute Cleveland Clinic Florida Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika K.","family":"Neicheril","sequence":"additional","affiliation":[{"name":"Department of Medicine, Internal Medicine Cleveland Clinic Florida Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Heart, Vascular, and Thoracic Institute Cleveland Clinic Florida Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Lafave","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart, Vascular, and Thoracic Institute Cleveland Clinic Abu Dhabi Abu Dhabi United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelenis Seijo De","family":"Armas","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Heart, Vascular, and Thoracic Institute Cleveland Clinic Florida Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Lewis","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of 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