{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:26:04Z","timestamp":1790868364682,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic heart failure (CHF) has always posed a significant threat to human survival and health. The efficacy of thiamine supplementation in CHF patients remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Receiving supplementary thiamine may not confer benefits to patients with CHF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive search was conducted across the Cochrane Library, PubMed, EMBASE, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>, and Web of Science databases up until May 2023 to identify articles investigating the effects of thiamine supplementation in CHF patients. Predefined criteria were utilized for selecting data on study characteristics and results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven randomized, double\u2010blind, controlled trials (five parallel trials and two crossover trials) involving a total of 274 patients were enrolled. The results of the meta\u2010analysis pooling these studies did not reveal any significant effect of thiamine treatment compared with placebo on left ventricular ejection fraction (WMD\u2009=\u20091.653%, 95% CI: \u200a\u22121.098 to 4.405, <jats:italic>p<\/jats:italic>\u2009=\u20090.239, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200961.8%), left ventricular end\u2010diastolic volume (WMD\u2009=\u2009\u22126.831\u2009mL, 95% CI: \u200a\u221226.367 to 12.704, <jats:italic>p<\/jats:italic>\u2009=\u20090.493, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%), 6\u2010min walking test (WMD\u2009=\u200916.526\u2009m, 95% CI: \u200a\u221236.582 to 69.634, <jats:italic>p<\/jats:italic>\u2009=\u20090.542, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200966.3%), N\u2010terminal pro\u2010B type natriuretic peptide (WMD\u2009=\u2009258.150\u2009pg\/mL, 95% CI: \u200a\u2212236.406 to 752.707, <jats:italic>p<\/jats:italic>\u2009=\u20090.306, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200921.6%), or New York Heart Association class (WMD\u2009=\u2009\u22120.223, 95% CI: \u200a\u22120.781 to 0.335, <jats:italic>p<\/jats:italic>\u2009=\u20090.434, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200987.1%). However, it effectively improved the status of thiamine deficiency (TD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our meta\u2010analysis indicates that thiamine supplementation does not have a direct therapeutic effect on CHF, except for correcting TD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24309","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T11:39:11Z","timestamp":1719574751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Role of Thiamine Supplementation in the Treatment of Chronic Heart Failure: An Updated Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"47","author":[{"given":"Shuai","family":"He","sequence":"first","affiliation":[{"name":"Department of Hand and Foot Surgery Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Rehabilitation Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingli","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Rehabilitation Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Rehabilitation Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minfang","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Rehabilitation Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Rehabilitation Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Rehabilitation Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Rehabilitation Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-7669","authenticated-orcid":false,"given":"Pengcheng","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Rehabilitation Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.106035"},{"issue":"18","key":"e_1_2_9_3_1","first-page":"e876","article-title":"2022 AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich P. 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