{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:03:00Z","timestamp":1778569380186,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Papillary muscle (PM) infarction (PMI) detected by cardiac magnetic resonance imaging (CMR) is associated with poor outcomes. Whether PM parameters provide more value for mitral regurgitation (MR) management currently remains unclear. Therefore, we examined the prognostic value of PMI using CMR in patients with MR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between March 2018 and July 2023, we retrospectively enrolled 397 patients with MR undergoing CMR. CMR was used to detect PMI qualitatively and quantitively. We also collected baseline clinical, echocardiography, and follow\u2010up data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 397 patients with MR (52.4\u2009\u00b1\u200913.9 years), 117 (29.5%) were assigned to the PMI group, with 280 (70.5%) in the non\u2010PMI group. PMI was demonstrated more in the posteromedial PM (PM\u2010PM, 98\/117) than in the anterolateral PM (AL\u2010PM, 45\/117). Compared with patients without PMI, patients with PMI had a decreased AL\u2010PM (41.5\u2009\u00b1\u20095.4 vs. 45.6\u2009\u00b1\u20095.3)\/PM\u2010PM diastolic length (35.0\u2009\u00b1\u20095.2 vs. 37.9\u2009\u00b1\u20094.0), PM\u2010longitudinal strain (LS, 20.4\u2009\u00b1\u20096.1 vs. 24.9\u2009\u00b1\u20094.6), AL\u2010PM\u2010LS (19.7\u2009\u00b1\u20096.8 vs.\u200924.7\u2009\u00b1\u20095.6)\/PM\u2010PM\u2010LS (21.2\u2009\u00b1\u20097.9 vs. 25.2\u2009\u00b1\u20096.0), and increased inter\u2010PM distance (25.7\u2009\u00b1\u20098.0 vs. 22.7\u2009\u00b1\u20096.2, all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multiple logistic regression analyses identified male sex (odds ratio [OR]\u2009=\u20093.65, 95% confidence interval\u2009=\u20091.881\u22127.081, p\u2009&lt;\u20090.001) diabetes mellitus (OR\/95% CI\/<jats:italic>p<\/jats:italic>\u2009=\u20092.534\/1.13\u20135.68\/0.024), AL\u2010PM diastolic length (OR\/95% CI\/<jats:italic>p<\/jats:italic>\u2009=\u20090.841\/0.77\u20130.92\/&lt;\u20090.001), PM\u2010PM diastolic length (OR\/95% CI\/<jats:italic>p<\/jats:italic>\u2009=\u20090.873\/0.79\u20130.964\/0.007), inter\u2010PM distance (OR\/95% CI\/<jats:italic>p<\/jats:italic>\u2009=\u20091.087\/1.028\u20131.15\/0.003), AL\u2010PM\u2010LS (OR\/95% CI\/<jats:italic>p<\/jats:italic>\u2009=\u20090.892\/0.843\u20130.94\/&lt;\u20090.001), and PM\u2010PM\u2010LS (OR\/95% CI\/<jats:italic>p<\/jats:italic>\u2009=\u20090.95\/0.9\u20130.992\/0.021) as independently associated with PMI. Over a 769\u2009\u00b1\u2009367\u2010day follow\u2010up, 100 (25.2%) patients had arrhythmia. Cox regression analyses indicated that PMI (hazard ratio [HR]\/95% CI\/<jats:italic>p<\/jats:italic>\u2009=\u20091.644\/1.062\u20132.547\/0.026), AL\u2010PM\u2010LS (HR\/95% CI\/<jats:italic>p<\/jats:italic>\u2009=\u20090.937\/0.903\u20130.973\/0.001), and PM\u2010PM\u2010LS (HR\/95% CI\/<jats:italic>p<\/jats:italic>\u2009=\u20090.933\/0.902\u20130.965\/&lt;\u20090.001) remained independently associated with MR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CMR\u2010derived PMI and LS parameters improve the evaluation of PM dysfunction, indicating a high risk for arrhythmia, and provide additive risk stratification for patients with MR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24312","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T10:42:36Z","timestamp":1719916956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Papillary Muscle Infarction by Cardiac MRI in Patients With Mitral Regurgitation"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-9230","authenticated-orcid":false,"given":"Jie","family":"Hou","sequence":"first","affiliation":[{"name":"College of Medicine and Biological Information Engineering Northeastern University  Shenyang Liaoning China"},{"name":"Department of Radiology General Hospital of Northern Theater Command  Shenyang China"},{"name":"Key Laboratory of Cardiovascular Imaging and Research of Liaoning Province  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Medicine and Biological Information Engineering Northeastern University  Shenyang Liaoning China"},{"name":"Department of Radiology General Hospital of Northern Theater Command  Shenyang China"},{"name":"Key Laboratory of Cardiovascular Imaging and Research of Liaoning Province  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6523-7488","authenticated-orcid":false,"given":"Huishan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology General Hospital of Northern Theater Command  Shenyang China"},{"name":"Key Laboratory of Cardiovascular Imaging and Research of Liaoning Province  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8609-3655","authenticated-orcid":false,"given":"Benqiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology General Hospital of Northern Theater Command  Shenyang China"},{"name":"Key Laboratory of Cardiovascular Imaging 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951117000439"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/cdt-22-301"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2020.01.67"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041497"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000411"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-20-3476"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.02.035"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-019-01726-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/acs-2021-ami-23"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000986"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-57"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.06.98"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.13.1759"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2022.05.006"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.07.084"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.08.016"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-115121"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-015-0213-1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.935338"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.931360"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-019-0761-3"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.06.036"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes210"}],"container-title":["Clinical 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