{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:21:44Z","timestamp":1778048504639,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The DESyne novolimus\u2010eluting coronary stent (NES) is a new\u2010generation drug\u2010eluting stent (DES) that is widely used, but clinical data are rarely reported for this stent. We compared the safety and effectiveness of the DESyne NES and the Orsiro bioresorbable polymer sirolimus\u2010eluting stent (SES) in patients undergoing percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective, single\u2010center, observational study. Between July 2017 and December 2022, patients who presented with chronic or acute coronary syndrome undergoing PCI with DESyne NES or Orsiro SES were consecutively enrolled in the present study. The primary endpoint, major adverse cardiovascular event (MACE), was a composite of cardiovascular death, target\u2010vessel myocardial infarction, or clinically driven target\u2010lesion revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 776 patients (age 68.8\u2009\u00b1\u200912.2; 75.9% male) undergoing PCI were included. Overall, 231 patients with 313 lesions received NES and 545 patients with 846 lesions received SES. During a follow\u2010up duration of 784\u2009\u00b1\u2009522 days, the primary endpoint occurred in 10 patients (4.3%) in the NES group and in 36 patients (6.6%) in the SES group. After multivariate adjustment, the risk of MACE did not significantly differ between groups (NES vs. SES, hazard ratio 0.74, 95% CI, 0.35\u20131.55, <jats:italic>p<\/jats:italic>\u2009=\u20090.425). The event rate of individual components of the primary endpoint was comparable between the\u00a0two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Favorable and similar clinical outcomes were observed in patients undergoing PCI with either NES or SES in a medium\u2010term follow\u2010up duration. Future studies with adequately powered clinical endpoints are required for further evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24317","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T12:41:22Z","timestamp":1719924082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010World Clinical Performance of a Novolimus\u2010Eluting Stent Versus a Sirolimus\u2010Eluting Stent"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2799-1185","authenticated-orcid":false,"given":"Chun\u2010Chin","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Ting","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2090-5558","authenticated-orcid":false,"given":"Ya\u2010Wen","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of Medicine, Division of Cardiology Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Ju","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin\u2010Hao","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of Medicine, Division of Cardiology Taipei City Hospital Yang Ming Branch Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2301-0255","authenticated-orcid":false,"given":"Yi\u2010Lin","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruey\u2010Hsing","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of Critical Care Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao\u2010Sung","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Healthcare and Services Center Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-6749","authenticated-orcid":false,"given":"Po\u2010Hsun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei 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