{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:17:40Z","timestamp":1791861460494,"version":"4.3.4"},"reference-count":72,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve implantation (TAVI) has been increasingly used in patients with severe aortic stenosis (AS). Since coronary artery disease (CAD) is common among these patients, it is crucial to choose the best method and timing of revascularization. This study aims to compare different timing strategies of percutaneous coronary intervention (PCI) in patients with severe AS undergoing TAVI to clarify whether PCI timing affects the patients' outcomes or not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A frequentist network meta\u2010analysis was conducted comparing three different revascularization strategies in patients with CAD undergoing TAVI. The 30\u2010day all\u2010cause mortality, in\u2010hospital mortality, all\u2010cause mortality at 1 year, 30\u2010day rates of myocardial infarction (MI), stroke, and major bleeding, and the need for pacemaker implantation at 6 months were analyzed in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our meta\u2010analysis revealed that PCI during TAVI had higher 30\u2010day mortality (RR\u2009=\u20092.46, 95% CI\u2009=\u20091.40\u20134.32) and in\u2010hospital mortality (RR\u2009=\u20091.70, 95% CI\u2009=\u2009[1.08\u20132.69]) compared to no PCI. Post\u2010TAVI PCI was associated with higher 1\u2010year mortality compared to other strategies. While no significant differences in major bleeding or stroke were observed, PCI during TAVI versus no PCI (RR\u2009=\u20093.63, 95% CI\u2009=\u20091.27\u201310.43) showed a higher rate of 30\u2010day MI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that among patients with severe AS and CAD undergoing TAVI, PCI concomitantly with TAVI seems to be associated with worse 30\u2010day outcomes compared with no PCI. PCI after TAVI demonstrated an increased risk of 1\u2010year mortality compared to alternative strategies. Choosing a timing strategy should be individualized based on patient characteristics and procedural considerations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24324","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T07:39:02Z","timestamp":1721979542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1002","volume":"47","author":[{"given":"Parisa","family":"Fallahtafti","sequence":"first","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Disease Research Institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"School of Medicine Tehran University of Medical Sciences  Tehran 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