{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:15:14Z","timestamp":1768551314736,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acute myocardial infarction (AMI) is a major global health concern. However, the optimum timing of coronary artery bypass grafting (CABG) in AMI patients remains controversial. This study investigated the optimal timing of CABG and its impact on postoperative outcomes. We hypothesized that determining the optimal timing of CABG could positively impact postoperative outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a nationwide retrospective analysis of the National Health Insurance Service of Korea database, focusing on 1\u2009705\u2009843 adult AMI patients diagnosed between 2007 and 2018 who underwent CABG within 1 year of diagnosis. Patients were categorized based on CABG timing. Primary endpoints included cohort identification and the time interval from AMI diagnosis to CABG. Secondary endpoints encompassed major adverse cardiac and cerebrovascular events (MACCEs) and the impact of postoperative medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the patients, 20\u2009172 underwent CABG. Surgery within 24\u2009h of AMI diagnosis demonstrated the most favorable outcomes, reducing cardiac death, myocardial infarction recurrence, and target vessel revascularization. Delayed CABG within 3 days also outperformed surgery within 1\u20132 days post\u2010AMI. Additionally, postoperative aspirin use was associated with improved MACCE outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CABG within 24\u2009h of AMI diagnosis was associated with significantly minimized myocardial injury, emphasizing the critical role of rapid revascularization. Delayed CABG within 3 days related to better outcomes compared with that of surgery within 1\u20132 days. These findings provide evidence\u2010based recommendations for optimizing CABG timing in AMI patients, consequentially reducing morbidity and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24325","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T07:05:28Z","timestamp":1723619128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optimal Revascularization Timing of Coronary Artery Bypass Grafting in Acute Myocardial Infarction"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-9674","authenticated-orcid":false,"given":"Hyo\u2010Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Surgery Ilsan Hospital Go\u2010Yang South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeongjee","family":"Lee","sequence":"additional","affiliation":[{"name":"Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics Yonsei University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Jong","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Severance Cardiovascular Hospital Yonsei University College of Medicine, Yonsei University Health System Seodaemun\u2010gu Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07492-2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211585"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2022.05.019"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.05.042"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5753"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/32.8.1596a"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.5.1290"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2003.75"},{"key":"e_1_2_12_9_2","unstructured":"Discussion119\u2013120."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.3.778"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.10.042"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.05.116"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.01.012"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.015279"},{"key":"e_1_2_12_15_1","first-page":"977","article-title":"ACC\/AHA guidelines for the Management of Patients With ST\u2010Elevation Myocardial Infarction\u2013Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction)","volume":"20","author":"Antman E. M.","year":"2004","journal-title":"The Canadian Journal of Cardiology"},{"issue":"124","key":"e_1_2_12_16_1","first-page":"e652","article-title":"2011 ACCF\/AHA Guideline for Coronary Artery Bypass Graft Surgery: A Report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"2011","author":"Hillis L. D.","year":"2011","journal-title":"Circulation"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35208-7"},{"key":"e_1_2_12_18_1","first-page":"540","article-title":"Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery \u2010 Unevenness of Daily Clinical Practice","volume":"60","author":"Sopek\u2010Merka\u0161 I.","year":"2022","journal-title":"Acta Clinica Croatica"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00206-9"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx419"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.06.003"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.24325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T03:47:50Z","timestamp":1724816870000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.24325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/clc.24325"],"URL":"https:\/\/doi.org\/10.1002\/clc.24325","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24325"}}