{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:58:21Z","timestamp":1760029101902},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T00:00:00Z","timestamp":1172448000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies indicated that local inflammation played a pivotal role in the pathogenesis of coronary heart disease. Soluble CD40 ligand (sCD40L) and hsC\u2010 reactive protein (hsCRP) are important inflammatory mediators. However, whether they can reflect local coronary inflammation is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that transcoronary concentration gradient of sCD40L could reflect local inflammation in patients with coronary heart disease (CHD) more reliably.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty subjects were divided into unstable angina pectoris (UAP) group (<jats:italic>n<\/jats:italic> = 20), stable angina pectoris (SAP) group (<jats:italic>n<\/jats:italic> = 10), and controls (<jats:italic>n<\/jats:italic> = 10). Blood samples were collected from the coronary sinus (CS), aortic root (AO), and femoral vein (FV). The coronary circulation was expressed as CS\u2010AO difference, while system circulation was expressed as FV\u2010AO difference. sCD40L and hs\u2010CRP were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complex lesions were more frequent in the UAP group than in the SAP group (85% vs. 40%, <jats:italic>p<\/jats:italic> &lt; 0.05). CS\u2010AO differences of sCD40L were much greater in the UAP group than in the SAP or control groups, and were greatly higher than FV\u2010AO difference in UAP group (465.49 \u00b1 247.85 pg\/mL vs. \u221214.94 \u00b1 83.41 pg\/mL; 465.49 \u00b1 247.85 pg\/mL vs. \u22127.66 \u00b1 78.54 pg\/mL; 465.49 \u00b1 247.85 pg\/mL vs. \u22127.99 \u00b1 141.34 pg\/mL, all <jats:italic>p<\/jats:italic> &lt; 0.001). CS\u2010AO differences of sCD40L were higher in patients with complex lesions than with smooth lesions (657.86 \u00b1 384.76 pg\/mL vs. 317.62 \u00b1 409.98 pg\/mL, <jats:italic>p<\/jats:italic> &lt; 0.01). There were no significant differences of CS\u2010AO in hs\u2010CRP among the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with CHD, the transcoronary concentration gradient of sCD40L is more sensitive than hsCRP, and sCD40L possibly a better marker of local inflammtion and plaque instability. Copyright \u00a9 2007 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.26","type":"journal-article","created":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T17:14:26Z","timestamp":1172510066000},"page":"86-91","source":"Crossref","is-referenced-by-count":20,"title":["Transcoronary concentration gradient of sCD40L and hsCRP in patients with coronary heart disease"],"prefix":"10.1002","volume":"30","author":[{"given":"Ying","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Wei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Sheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Yong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Xia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00309-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021993"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-1738(01)00142-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hh2401.101272"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.6.614"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000025419.95769.F0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4401.099447"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.476903"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80207-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00472-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.65.247"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000136588.62638.5E"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022600"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000088521.04017.13"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.09.051"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000028962.04520.01"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.029"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.26","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T20:04:32Z","timestamp":1700078672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1002\/clc.26"],"URL":"https:\/\/doi.org\/10.1002\/clc.26","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}