{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:17:21Z","timestamp":1699316241102},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:00:00Z","timestamp":1383177600000},"content-version":"vor","delay-in-days":12632,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1979,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>18 patients with acute myocardial infarction and sustained arrhythmias were treated with a new Ca<jats:sup>2+<\/jats:sup> antagonist, Ro 11\u20101781, at the dose of 1.0 mg\/kg i.v. The drug was effective in reducing heart rate to less than 90 beats\/min in 9\/10 patients with atrial fibrillation, in 3\/4 patients with atrial flutter and in 3\/4 patients with supraventricular tachycardia. The peak effect was observed within 2\u20105 min after the intravenous administration of Ro 11\u20101781. In cases with recurring tachyarrhythmias, the drug was also effective in repetitive administration. Systolic blood pressure was reduced, but severe hypotension (&lt; 90 mm Hg) was not observed. The atrioventricular conduction in these patients remained unimpaired and asystole did not occur. The drug appears to be an effective and a well tolerated antiarrhythmic agent.<\/jats:p>","DOI":"10.1002\/clc.4960020208","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T12:31:40Z","timestamp":1383222700000},"page":"131-134","source":"Crossref","is-referenced-by-count":7,"title":["Dimeditiapramine (Ro 11\u20101781), a new calcium antagonist, in the management of supraventricular tachyarrhythmias in patients with acute myocardial infarction"],"prefix":"10.1002","volume":"2","author":[{"given":"G.","family":"Cocco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Strozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,31]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5806.169-b"},{"key":"e_1_2_1_3_2","first-page":"268","article-title":"Die Beeinflussung systolischer und elektrokardiographischer Zeitintervalle herzgesunder Patienten durch den Kalziumantagonisten Ro 11\u20131781","volume":"67","author":"Bischoff KO","year":"1978","journal-title":"Z Kardiol"},{"key":"e_1_2_1_4_2","unstructured":"CoccoG. StrozziC.: Effetti cardiovascolari di un nuovo farmaco calcio\u2010antagonista (Ro 11\u20131781) nella fibrillazione atriale.Boll Chim Farmac(In press)."},{"key":"e_1_2_1_5_2","first-page":"923","article-title":"Cardiovascular effects of calcium antagonists in chronically instrumented dogs","volume":"34","author":"Eigenmann R.","year":"1978","journal-title":"Experientia"},{"key":"e_1_2_1_6_2","first-page":"81","article-title":"Die Wirkung eines neuen Kalzium\u2010Antagonisten (Ro 11\u20131781) bei supraventrikul\u00e4ren paroxysmalen Tachykardien","volume":"16","author":"Gmeiner R.","year":"1978","journal-title":"Adv Clin Pharmocol"},{"key":"e_1_2_1_7_2","first-page":"238","article-title":"Die Wirkung von Ro 11\u20131781, einem Kalziumantagonisten, auf die atrioventrikul\u00e4re \u00dcberleitung","volume":"66","author":"Gmeiner R.","year":"1977","journal-title":"Z Kardiol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.57.4.751"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(75)90431-7"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90566-0"},{"key":"e_1_2_1_11_2","first-page":"157","article-title":"Asystolie suivie de choc cardiog\u00e9nique apr\u00e8s injection intraveineuse de v\u00e9rapamil","volume":"24","author":"Mott\u00e9 G.","year":"1975","journal-title":"Ann Cardiol Ang\u00e9iol"},{"key":"e_1_2_1_12_2","unstructured":"RabergerG. 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