{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:31:53Z","timestamp":1757701913165},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:00:00Z","timestamp":1383177600000},"content-version":"vor","delay-in-days":12571,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1979,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cardiac electrophysiological effects of sotalol were studied in ten patients (pts) aged 20\u201065 years undergoing intracardiac stimulation studies for palpitations (7 pts) or dizzy spells (3 pts). The following measurements were made: 1. basic sinus cycle length (SCL); 2. sinus node recovery time (SNRT) following overdrive pacing; 3. intra\u2010atrial (PA), atrio\u2010His (AH) and His\u2010ventricular (HV) conduction intervals during regular atrial pacing; 4. effective refractory periods of the atria (AERP), AV node (AVERP) and ventricular myocardium (VERP). AV nodal functional refractoriness (AVFRP) was also determined. All measurements were repeated 10\u201015 min after i.v. administration of 0.4 mg\/kg of sotalol. Results were analysed by the Wilcoxon Signed Rank test. Significant increases in SCL (p &lt; 0.01), AH (p &lt; 0.01), SNRT (p &lt; 0.01), AVERP (p &lt; 0.02) and AVFRP (p &lt; 0.01) were observed. These effects are consistent with the beta\u2010blocking action of sotalol. The acute increase in AERP (p &lt; 0.01) is, however, not a common property of other betablockers and may be related to the \u2018class III\u2019 cellular effect of sotalol. These results are discussed in relationship to the electrophysiological effects of other beta\u2010blocking drugs.<\/jats:p>","DOI":"10.1002\/clc.4960020303","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T12:32:55Z","timestamp":1383222775000},"page":"185-191","source":"Crossref","is-referenced-by-count":39,"title":["The acute cardiac electrophysiological effects of intravenous sotalol hydrochloride"],"prefix":"10.1002","volume":"2","author":[{"given":"D. E.","family":"Ward","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Camm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A. 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Br J Pharmacol"},{"key":"e_1_2_1_26_2","volume-title":"A study of the pharmacological actions of certain drugs and hormones with particular reference to cardiac muscle","author":"Singh BN","year":"1971"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.26.6.661"},{"key":"e_1_2_1_28_2","first-page":"341","volume-title":"Recent advances in beta\u2010adrenergic blocking therapy \u2014 sotalol","author":"Stroobrandt R.","year":"1974"},{"key":"e_1_2_1_29_2","first-page":"341","volume-title":"Recent advances in beta\u2010adrenergic blocking therapy \u2014 sotalol","author":"Tackels R.","year":"1974"},{"key":"e_1_2_1_30_2","first-page":"417","article-title":"Etudes des *propri\u00e9t\u00e9s electrophysiologiques de l'acebutolol chez l'homme","volume":"30","author":"Touboul P.","year":"1975","journal-title":"Therapie"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(66)90062-2"},{"key":"e_1_2_1_32_2","first-page":"449","volume-title":"Symposium on cardiac arrhythmias","author":"Vaughan\u2010Williams EM","year":"1970"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.27.3.345"},{"key":"e_1_2_1_34_2","first-page":"795","article-title":"Electrophysiology and pharmacology of cardiac arrhythmias IX","volume":"90","author":"Wit AL","year":"1975","journal-title":"Cardiac electrophysiological effects of beta\u2010adrenergic receptor stimulation and blockade. 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