{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T03:45:35Z","timestamp":1759117535752},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:00:00Z","timestamp":1233705600000},"content-version":"vor","delay-in-days":10658,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1979,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have reported that thromboxane B<jats:sub>2<\/jats:sub> is present in plasma of Prinzmetal's angina patients measured by radioimmunoassay but is below detection limits, &lt;0.5 pmol\/ml, in normals. To determine whether this metabolite of thromboxane A<jats:sub>2<\/jats:sub> (a coronary vasoconstrictor) is present in the peripheral blood in classical angina pectoris, we studied 14 patients with fixed obstructive coronary artery disease (2.5 lesions per patient) in whom angina was induced by atrial pacing. Thromboxane B<jats:sub>2<\/jats:sub> at rest was barely detectable (0.537\u00b10.16 pmol\/ml), but rose during pacing (0.747\u00b10.18 pmol\/ml) and was maximal (p&lt;0.05) 5\u201310 min after pacing (1.237\u00b10.36 pmol\/ml). In eight variant angina patients, resting levels of thromboxane B<jats:sub>2<\/jats:sub> were not statistically different during spontaneous angina and angina\u2010free intervals (2.837\u00b10.56 and 1.577\u00b10.34 pmol\/ml), but the mean 5\u201310 min after angina was higher than during angina (6.41 7\u00b11.46 pmol). The means of preanginal, anginal, and postanginal samples were all higher than the corresponding means of the classical angina group, and thromboxane B<jats:sub>2<\/jats:sub> levels in variant angina patients in the absence of angina, during angina, and 5\u201310 min after angina were all significantly higher (p&lt;0.025) compared to the classical angina group measured prior to pacing. Unlike the case with variant angina, thromboxane B<jats:sub>2<\/jats:sub> is indetectable in classical angina pectoris patients at rest. Furthermore, spontaneous angina in variant angina or pacing\u2010induced angina in classical angina pectoris are both followed by increased thromboxane B<jats:sub>2<\/jats:sub>, although the latter responses are smaller. The role of these phenomena in the pathogenesis of coronary artery spasm and ischemia remains to be clarified.<\/jats:p>","DOI":"10.1002\/clc.4960020603","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T14:51:54Z","timestamp":1233759114000},"page":"404-406","source":"Crossref","is-referenced-by-count":48,"title":["Comparison of plasma concentrations of thromboxane B<sub>2<\/sub> in prinzmetal's variant angina and classical angina pectoris"],"prefix":"10.1002","volume":"2","author":[{"given":"R. I.","family":"Lewy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Wiener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Walinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Silver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Saia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(74)80130-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0005-2760(76)90198-3","article-title":"Metabolism of 14C\u2010arachidonic acid by human platelets","volume":"424","author":"Bills TK","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_1_4_2","first-page":"361","article-title":"Development and application of a radioimmunoassay for F prostaglandins","volume":"9","author":"Caldwell BV","journal-title":"J Reprod Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1126\/science.959827","article-title":"Coronary arterial smooth muscle contraction by a substance released from platelets. Evidence that it is thromboxane A2","volume":"193","author":"Ellis EF","journal-title":"Science"},{"key":"e_1_2_1_6_2","first-page":"20","article-title":"Radioimmunoassay of thromboxane B2","volume":"38","author":"Ferraris V","journal-title":"Thromb Haemostasis"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.8.2994"},{"key":"e_1_2_1_8_2","first-page":"695","article-title":"Coronary artery spasm","volume":"229","author":"Hillis LD","journal-title":"N Engl J Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0090-6980(77)90233-7","article-title":"Metabolism of thromboxane B2 in the cynomolgus monkey","volume":"13","author":"Kindahl H","journal-title":"Prostaglandins"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-4630(79)90059-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.945611"},{"key":"e_1_2_1_12_2","first-page":"H400","article-title":"Actions of prostaglandins on isolated perfused cat coronary arteries","volume":"235","author":"Ogletree ML","year":"1978","journal-title":"Am J Physiol"},{"key":"e_1_2_1_13_2","first-page":"205","volume-title":"Statistical Methods","author":"Snedecor W","year":"1967"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/274064a0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(76)90128-3"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0022-5223(19)41250-6","article-title":"Therapeutic implications of myocardial lactate metabolism in patients considered for emergency myocardial revascularization","volume":"75","author":"Wiener L","year":"1978","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960020603","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960020603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:00:22Z","timestamp":1696615222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960020603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1979,12]]}},"alternative-id":["10.1002\/clc.4960020603"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960020603","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,12]]}}}