{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:18:39Z","timestamp":1699402719615},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":12129,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1981,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The hemodynamic effects of a new cardioselective beta agonist, prenalterol, were evaluated in 12 patients with moderate or severe impairment of left ventricular function due to coronary heart disease or primary cardiomyopathy. In doses up to 7 mg the drug led to a substantial increase of left ventricular pressure rise (+55%) and mean circumferential fiber shortening (+59%) and a decrease of left ventricular end\u2010diastolic pressure (\u201352%), mean pulmonary artery pressure (\u201324%) and pulmonary vascular resistance (\u201337%) indicating augmented myocardial contractility and reduced left ventricular preload. Cardiac output was increased only in 4 of 12 patients, heart rate, left ventricular systolic and mean right atrial pressures and the pressure\u2010rate product as an index for myocardial oxygen demand remained essentially unchanged. The same is true for stroke index, stroke work index, total peripheral resistance, left ventricular end\u2010diastolic and end\u2010systolic volume and ejection fraction. The positive inotropic effect was achieved with good tolerance and without arrhythmogenic or other side effects. Prenalterol may be especially useful in patients with low sympathetic activity and hypotension. In patients with diffuse congestive cardiomyopathy, high sympathetic activity, pronounced peripheral vasoconstriction and normal blood pressure, vasodilator therapy alone or in combination with prenalterol should be considered.<\/jats:p>","DOI":"10.1002\/clc.4960040604","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T11:35:46Z","timestamp":1421408146000},"page":"325-329","source":"Crossref","is-referenced-by-count":2,"title":["Hemodynamic assessment of prenalterol: A cardioselective beta agonist in patients with impaired left ventricular function"],"prefix":"10.1002","volume":"4","author":[{"given":"W.","family":"Klein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"AwanN: Evaluation of prenalterol dose\u2010response and comparative hemodynamic assessments.Prenalterol Workshop. Hamburg(1980)."},{"key":"e_1_2_1_3_1","first-page":"287","volume-title":"Symposium on Digitalis.","author":"Beller GA","year":"1973"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00505039"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-3-421"},{"key":"e_1_2_1_6_1","first-page":"184","article-title":"Die Wirkung von Prenalterol bei schwerer Herzinsuffizienz. Z","volume":"69","author":"Doering W","year":"1980","journal-title":"Kardiol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90427-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","unstructured":"DrexlerH: Acute and long\u2010term effects of a combination of hydralazine and prenalterol in chronic congestive heart failure.Prenalterol Workshop. Hamburg(1980).","DOI":"10.1007\/BF02593856"},{"key":"e_1_2_1_9_1","unstructured":"FiorentiniC: Circulatory responses to prenalterol in normal subjects and in patients with congestive cardiomyopathy.Prenalterol Workshop. Hamburg(1980)."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(77)90007-X"},{"key":"e_1_2_1_11_1","unstructured":"Hjalmarson\u00c5: Oral and intravenous administration of prenalterol to patients with severe congestive heart failure.Prenalterol Workshop. Hamburg(1980)."},{"key":"e_1_2_1_12_1","unstructured":"KirlingPC: Intravenous prenalterol in patients with severe heart failure.Prenalterol Workshop. Hamburg(1980)."},{"key":"e_1_2_1_13_1","unstructured":"KupperW: Hemodynamic and metabolic effects of prenalterol in patients with severe left heart failure.Prenalterol Workshop. Hamburg(1980)."},{"key":"e_1_2_1_14_1","first-page":"705","article-title":"Die Wirkung von Prenalterol bei Patienten mit hochgradig eingeschr\u00e4nkter linksventrikul\u00e4rer Funktion","volume":"69","author":"Leinberger H","year":"1980","journal-title":"Z Kardiol"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(78)90642-2"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.1980.3.2.96"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(68)90089-6"},{"key":"e_1_2_1_18_1","unstructured":"ScuppanU: Oral administration of prenalterol to patients with left ventricular failure.Prenalterol Workshop. Hamburg(1980)."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1976.tb06694.x"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960040604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960040604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T05:22:45Z","timestamp":1699334565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960040604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,11]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1981,11]]}},"alternative-id":["10.1002\/clc.4960040604"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960040604","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,11]]}}}