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Eighteen patients responded after a loading oral dose of 300 mg disopyramide with 80% or greater reduction in VPD and abolition of advanced grades. Mean onset of drug action was 93 min and the mean plasma level at 2 h was 3.4 \u03bcg\/ml. During maintenance therapy 2 of the 18 patients had a relapse. In 2 others, initially protected, VPD recurred during both exercise and psychological stress testing. STI showed increments in pre\u2010ejection period (PEP) and in PEP\/ejection time ratio at peak concentrations of plasma disopyramide. Acute tests repeated with placebo in a single\u2010blind fashion in responding patients failed to significantly reduce VPD frequency or grade. Side effects consisted of anticholinergic actions of disopyramide. 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