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Radionuclide ventriculography was carried out after injection of 20 mCi <jats:sup>99m<\/jats:sup>technetium\u2010labeled red blood cells. Time\u2010activity curves were obtained from the left and right ventricular regions, and the ratio (A) of end\u2010diastolic\u2010end\u2010systolic count rate differences for the left and right ventricles was calculated. The left\u2010to\u2010right shunt (in percent of the\u2010pulmonary flow rate) is then given as 100 \u00d7 (1 \u2013 A\/1.43); 1.43 being the previously determined mean value of A in 66 normal patients. In 16 patients with an atrial septal defect and\/or partial anomalous pulmonary venous connection a correlation of r = 0.81 was found between those shunts determined by the scintigraphic method and those calculated by oxymetric data. The specificity of the method and the sensitivity in detecting left\u2010to\u2010right shunts exceeding 30% are high. The method is practical and already widely used for determination of ejection fraction, end\u2010diastolic volume and other factors. The combination of this technique with other methods for shunt diagnosis such as gamma\u2010fit analysis may prove of special value.<\/jats:p>","DOI":"10.1002\/clc.4960050301","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T11:37:26Z","timestamp":1421408246000},"page":"192-200","source":"Crossref","is-referenced-by-count":5,"title":["Radionuclide ventriculography: A noninvasive method for the detection and quantification of left\u2010to\u2010right shunts in atrial septal defect"],"prefix":"10.1002","volume":"5","author":[{"given":"P.","family":"Kress","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bitter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Stauch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Garvie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Nechwatal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sigel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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