{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:51:01Z","timestamp":1758397861553},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:00:00Z","timestamp":1233705600000},"content-version":"vor","delay-in-days":9776,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1982,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: The cardiac electrophysiological effects of metoprolol were studied in ten patients (pts) aged 22\u201351 years undergoing intracardiac stimulation studies for paroxysmal palpitations. The following measurements were made: (1) basic sinus cycle length (SCL); (2) sinus node recovery time (SRT) following overdrive pacing; (3) atrio\u2010His (A\u2010H) and His\u2010ventricular (H\u2010V) conduction intervals during regular atrial pacing; (4) effective refractory periods of the atria (AERP), A\u2010V node (AVERP) and ventricular myocardium (VERP); and (5) A\u2010V nodal functional refractory period (AVFRP). All measurements were repeated 10\u201320 min after a slow bolus intravenous injection of metoprolol (0.2 mg\/kg body weight). Results were analyzed by the Wilcoxon Signed Rank test. Highly significant increases in: SRT (932\u00b1166 to 1107\u00b1225 ms, p&lt;0.001) and A\u2010H (72\u00b114 to 103\u00b1 14 ms, p&lt;0.001) were observed. There were also small increases of lesser significance in SCL (794\u00b1 160 to 898\u00b1190 ms, p&lt;0.01), AVERP (308\u00b146 to 341\u00b166 ms, p&lt;0.02), and AVFRP (376\u00b143 to 416\u00b159 ms, p&lt;0.01). Metoprolol did not affect the H\u2010V interval, the AERP, or the VERP. These results are similar to those of other beta blockers.<\/jats:p>","DOI":"10.1002\/clc.4960050503","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T13:51:27Z","timestamp":1233755487000},"page":"327-331","source":"Crossref","is-referenced-by-count":6,"title":["The acute electrophysiological effects of intravenous metoprolol"],"prefix":"10.1002","volume":"5","author":[{"given":"A. J.","family":"Camm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. B.","family":"Whitmarsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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