{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T20:55:29Z","timestamp":1715547329557},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:00:00Z","timestamp":1233705600000},"content-version":"vor","delay-in-days":9715,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1982,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report 13 patients with unequivocal Prinzmetal's variant angina pectoris as the entire experience with this syndrome during a 7\u2010year period in a single institution. The clinical diagnosis of this relatively uncommon disorder is emphasized. Five patients were given 10 mg of methacholine subcutaneously. Three demonstrated subsequent delayed appearance of chest pain, ECG change, and coronary vasospasm following early appearance of muscarinic effects. Two Prinzmetal patients had no provocation of variant angina following methacholine, though they did experience significantly less blood pressure fall in response to muscarinic provocation. Another 23 subjects with incompletely explained chest pain given methacholine had neither ECG change nor spasm. Methacholine provocation of variant angina need not necessarily implicate a parasympathomimetic mechanism for otherwise spontaneous episodes. Rather, provocation would appear to occur via the customary reflex adrenergic response to drug\u2010induced hypotension. Methacholine is probably safe though unreliable as an agent to be used for spasm provocation.<\/jats:p>","DOI":"10.1002\/clc.4960050702","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T13:45:31Z","timestamp":1233755131000},"page":"393-402","source":"Crossref","is-referenced-by-count":11,"title":["Methacholine provocation of prinzmetal's variant angina pectoris: A revised perspective"],"prefix":"10.1002","volume":"5","author":[{"given":"J. M.","family":"Stang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Kolibash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Schorling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.39.8.911"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1177\/070674377101600510","article-title":"Blood pressure\/pulse response to intravenous methacholine in psychiatric illness","volume":"16","author":"Baker EFW","year":"1971","journal-title":"Can Psychiatr Assoc J"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.141.6.716"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90080-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.59.1.82"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.59.2.307"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(79)90199-4"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197601292940505"},{"key":"e_1_2_1_10_1","first-page":"II\u2010265","article-title":"Exercise induced coronary spasm: \u03b1\u2010adrenergic mechanism? (Abstract)","volume":"60","author":"Freedman B","year":"1979","journal-title":"Circulation"},{"key":"e_1_2_1_11_1","volume-title":"Autonomic Imbalance and the Hypothalamus. 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