{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:33:26Z","timestamp":1780529606287,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":11764,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1982,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sixteen patients with progressive systemic sclerosis (PSS), including 3 with the \u201cCREST\u201d (calcinosis, Raynaud's, esophageal dysfunction, sclerodactyly, and\/or telangiectasias) variant, were evaluated with resting M\u2010mode echocardiography and noninvasive measurements of cardiac output at rest and during submaximal exercise to determine the nature and extent of any cardiovascular impairment. No patient had arterial hypertension, significant renal impairment, clinical evidence of large vessel coronary artery disease, or severe pulmonary dysfunction. The duration of disease was 1 to 12 years (9 to 30 for patients with the CREST variant). Echocardiographic abnormalities included increased right ventricular dimension (3 patients), reduced left ventricular ejection fraction (3 patients), and pericardial effusion (3 patients). Cardiac index (CI) and stroke volume index (SVI) at rest were similar for patients and controls. Patients and controls were exercised to similar heart rates (130\u00b13 vs 124\u00b14; p, NS). Total peripheral resistance (TPR) was higher for patients (1123\u00b181 vs 810\u00b144 dyn\u00b7s\u00b7cm<jats:sup>\u22125<\/jats:sup>) and their mean SVI failed to increase significantly compared with sitting rest values (30\u00b12 vs 35\u00b13 ml\/m<jats:sup>2<\/jats:sup>). The control subjects had the expected increase in SVI (36\u00b12 vs 51 \u00b15; p &lt; 0.01). Ten patients with an abnormal hemodynamic response to exercise had a normal echocardiographic circumferential fiber shortening (V<jats:sub>CF<\/jats:sub>) or ejection fraction (EF) at rest. The data indicate that PSS patients have a greater degree of cardiovascular dysfunction than would be predicted from clinical data and laboratory evaluation of cardiovascular and pulmonary function at rest. Multiple mechanisms, including right and left ventricular dysfunction and abnormal vasoconstrictor activity, are likely to contribute to the reduction in exercise capacity seen in patients with PSS.<\/jats:p>","DOI":"10.1002\/clc.4960051101","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T11:40:18Z","timestamp":1421408418000},"page":"569-576","source":"Crossref","is-referenced-by-count":16,"title":["Cardiovascular function in patients with progressive systemic sclerosis (scleroderma)"],"prefix":"10.1002","volume":"5","author":[{"given":"F. A.","family":"Gaffney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. V.","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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