{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T04:16:27Z","timestamp":1747455387935,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":11613,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1983,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The failure of changes in autonomic drive to affect heart rate is a common finding in patients with the sick sinus syndrome (SSS). The normal respiratory sinus arrhythmia is vagally mediated and should therefore be attenuated in SSS. This hypothesis was tested in a series of 32 symptomatic patients with SSS, mean age 68 years, and an age\u2010matched control group of 75 normal subjects. The degree of sinus arrhythmia present in routine 12\u2010lead electrocardiograms was quantitated as (1) the coefficient of variation (CV) of the R\u2010R interval, and (2) the maximal R\u2010R interval difference (\u0394R\u2010R<jats:sub>max<\/jats:sub>). Mean CV was 2.7% in SSS compared to 3.8% in the control group (p &lt; 0.01). Mean \u0394R\u2010R<jats:sub>max<\/jats:sub>was 72 ms in SSS and 140 ms in controls (p &lt; 0.01). Sixteen of 32 patients (50%) compared to only 4\/75 (5%) control subjects had \u0394R\u2010R<jats:sub>max<\/jats:sub>of less than 80 ms (p &lt; 0.01). Thus, SSS is frequently associated with a significant attenuation of sinus arrhythmia and the simple measurement of \u0394R\u2010R<jats:sub>max<\/jats:sub>in standard ECG recordings provides useful diagnostic information.<\/jats:p>","DOI":"10.1002\/clc.4960060401","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T11:42:12Z","timestamp":1421408532000},"page":"151-154","source":"Crossref","is-referenced-by-count":2,"title":["Absence of respiratory sinus arrhythmia: A manifestation of the sick sinus syndrome"],"prefix":"10.1002","volume":"6","author":[{"given":"E.","family":"Grassman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. G.","family":"Blomqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.36.3.359"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197110142851602"},{"key":"e_1_2_1_4_1","first-page":"279A","article-title":"Sinus arrhythmia (SA) as an index of vagal tone","volume":"22","author":"Harris MD","year":"1974","journal-title":"Clin Res"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0031-6997(25)06588-3","article-title":"Parasympathetic control of the heart","volume":"25","author":"Higgins CB","year":"1973","journal-title":"Pharmacol Rev"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.57.2.217"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.39.5.801"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.28.3.381"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.44.1.59"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1975.00330030038004"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.37.8.882"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1953.5.9.508"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.46.1.5"},{"key":"e_1_2_1_14_1","first-page":"510","article-title":"Untersuchungen \u00fcber die physiologische Unregelm\u00e4ssigkeit des Herzschlages; \u00fcber die Abh\u00e4ngigkeit der respiratorischen (Ruhe\u2010) Arrhythmie von der Schlagfrequenz und vom Lebensalter","volume":"29","author":"Schlomka G","year":"1937","journal-title":"Ztschr. f. Kreislaufforsch"},{"key":"e_1_2_1_15_1","first-page":"93","volume-title":"Differentiation Between Normal and Abnormal Electrocardiography.","author":"Simonson E","year":"1961"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960030606"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0736(77)80048-4"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1001\/archinte.1976.03630040016004","article-title":"Prognosis of patients permanently paced for sick sinus syndrome","volume":"136","author":"Wohl AJ","year":"1976","journal-title":"Arch Int Med"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960060401","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960060401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T23:56:33Z","timestamp":1747439793000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960060401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1983,4]]}},"alternative-id":["10.1002\/clc.4960060401"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960060401","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"type":"print","value":"0160-9289"},{"type":"electronic","value":"1932-8737"}],"subject":[],"published":{"date-parts":[[1983,4]]}}}