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As amiodarone has been used more widely and in more diverse patient populations, reports of serious thyroid, pulmonary, cardiovascular, and other adverse reactions have appeared in the literature. In this paper, we review the serious adverse effects that have been reported to date. The incidence of these reactions varies considerably in different series, and cannot be explained solely by different doses employed or by varying methods of drug administration. The final role of amiodarone in the therapy of cardiac arrhythmias cannot be determined until the long\u2010term toxicity has been more thoroughly investigated.<\/jats:p>","DOI":"10.1002\/clc.4960070302","type":"journal-article","created":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:51:01Z","timestamp":1233795061000},"page":"131-137","source":"Crossref","is-referenced-by-count":24,"title":["Serious adverse effects of amiodarones"],"prefix":"10.1002","volume":"7","author":[{"given":"B.","family":"Mc GOVERN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Garan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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