{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T17:40:40Z","timestamp":1697910040200},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:00:00Z","timestamp":1233705600000},"content-version":"vor","delay-in-days":8741,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eight patients with primary pulmonary hypertension underwent systolic time intervals, M\u2010mode echocardiography, and direct hemodynamic studies in order to determine the correlation between noninvasive parameters and hemodynamic variables and to evaluate the utility of these noninvasive studies in primary pulmonary hypertension. The ratio of the pre\u2010ejection period to left ventricular ejection time (PEP\/LVET) of the systolic time intervals was abnormally increased (&gt;0.42) for each subject; the increase in the PEP\/LVET was secondary to a shortening of the left ventricular ejection time in four patients, prolongation of the pre\u2010ejection period in one, or a combination of such, noted in three patients. In contrast, echocardiographic parameters of left ventricular function, specifically percent change in the minor axis of the left ventricle with systole, velocity of circumferential fiber shortening, and ejection fraction, were normal. In addition, a very good correlation was noted between PEP\/LVET and total pulmonary resistance (r value = \u22120.89, p&lt;0.05), while the echocardiographic parameters correlated well with stroke volume and cardiac output (r values ranged from 0.68 to 0.72, p&lt;0.05). These results indicate that in primary pulmonary hypertension, the performance of both systolic time intervals and M\u2010mode echocardiography noninvasively provides useful information concerning the hemodynamic status of these patients. Systolic time intervals provide an estimation of overall cardiac\u2010cardiovascular performance, rather than left ventricular function alone, which in turn, is validly examined by M\u2010mode echocardiography.<\/jats:p>","DOI":"10.1002\/clc.4960080309","type":"journal-article","created":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T05:09:34Z","timestamp":1233810574000},"page":"166-172","source":"Crossref","is-referenced-by-count":1,"title":["Combining left ventricular systolic time intervals and M\u2010mode echocardiography in the evaluation of primary pulmonary hypertension in women"],"prefix":"10.1002","volume":"8","author":[{"given":"C. V.","family":"Leier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sahar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Hermiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. V.","family":"Unverferth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.50.2.317"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.6.3.319"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.46.5.914"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.46.1.26"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106048"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(71)90084-1"},{"key":"e_1_2_1_8_1","first-page":"301","volume-title":"Noninvasive Cardiology","author":"Lewis RP","year":"1974"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1152\/ajplegacy.1926.77.2.263","article-title":"The duration of systole of the left ventricle in man","volume":"77","author":"Lombard WP","year":"1926","journal-title":"Am J Physiol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.46.1.14"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.41.3.485"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.68.2.135"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.12.6.611"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(61)90403-3"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960080309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960080309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T16:01:03Z","timestamp":1697817663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960080309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,3]]}},"alternative-id":["10.1002\/clc.4960080309"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960080309","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}