{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:46Z","timestamp":1786977406112,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":8650,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1985,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Flecainide is reported to be effective in patients with paroxysmal tachycardias, but its effect on rapid ventricular response over accessory atrioventricular pathway during atrial fibrillation is not known. The influence of flecainide on various electrophysiological properties of the accessory pathway with special emphasis on ventricular rate during atrial fibrillation was investigated in 9 patients with severe symptomatic Wolff\u2010Parkinson\u2010White syndrome. The shortest ventricular response during atrial fibrillation increased from 218 (190\u2010270) to 320 (240\u2010block) ms. In 4 patients sustained rapid atrial fibrillation converted to sinus rhythm. The rate of circus movement tachycardia decreased from 166\/min to 130\/min after flecainide, due to a lengthening of retrograde ventriculoatrial conduction time over the accessory pathway. Flecainide caused a significant prolongation of the effective refractory period of the accessory pathway in our subgroup with extremely fast AV conduction during atrial fibrillation and induced a depressant effect on retrograde accessory pathway conduction. This makes the drug very promising for the emergency treatment of dangerous rapid tachyarrhythias complicating this syndrome.<\/jats:p>","DOI":"10.1002\/clc.4960080603","type":"journal-article","created":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T02:50:25Z","timestamp":1233802225000},"page":"321-326","source":"Crossref","is-referenced-by-count":37,"title":["Evaluation of flecainide acetate in rapid atrial fibrillation complicating wolff\u2010parkinson\u2010white syndrome"],"prefix":"10.1002","volume":"8","author":[{"given":"L. J.","family":"Kappenberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Fromer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shenasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. O.","family":"Gloor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.63.2.435"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/oxfordjournals.eurheartj.a061432","article-title":"A comparison of the anti\u2010arrhythmic effects on AV\u2010junctional re\u2010entrant tachycardia of oral and intravenous flecainide acetate","volume":"4","author":"Bexton RS","year":"1983","journal-title":"Eur Heart J"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.43.4.520"},{"key":"e_1_2_1_5_1","first-page":"1672","article-title":"Die Bedeutung der elektrophysiologischen Herzuntersuchung bei akzessorischer atrio\u2010ventrikularer Verbindung","volume":"110","author":"Kappenberger L","year":"1980","journal-title":"Schweiz Med Wschr"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90192-9"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197911153012003"},{"key":"e_1_2_1_8_1","first-page":"7","article-title":"Effects of flecainide on electrophysiological properties of accessory pathways in the Wolff\u2010Parkinson\u2010White syndrome","volume":"34","author":"Neuss H","year":"1983","journal-title":"Eur Heart J 4"},{"key":"e_1_2_1_9_1","first-page":"524","article-title":"Elektrophysiologische Effekte des neuen Anti\u2010arrhythmikums Flecainid beim Menschen","volume":"70","author":"Seipel L","year":"1981","journal-title":"Z Kardiol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.56.2.260"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(74)90695-X"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.37.3.231"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90230-1"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960080603","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960080603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T13:27:59Z","timestamp":1697808479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960080603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1985,6]]}},"alternative-id":["10.1002\/clc.4960080603"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960080603","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,6]]}}}