{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T23:21:13Z","timestamp":1747696873984},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T00:00:00Z","timestamp":1233705600000},"content-version":"vor","delay-in-days":8496,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Approximately 10\u201320% of patients with auscultatory evidence of mitral valve prolapse (MVP) have \u201cfalse negative\u201d echocardiograms. Pharmacological maneuvers do not significantly improve the sensitivity and may cause side effects. It is well known that auscultatory features of MVP change and not uncommonly can be heard only in the standing position. Therefore M\u2010mode echo was performed in both supine and standing positions in 10 normal control subjects and 25 patients of comparable age and sex who had auscultatory evidence of MVP but negative echo in supine position. All 10 control subjects had normal echo in both supine and standing positions. No instance of false positive MVP was noted. Of the 25 patients with \u201cfalse negative\u201d supine echo, 5 showed evidence of MVP (3 pansystolic and 2 late systolic) in standing position. Based on these results the following conclusions were reached. (1) In normal individuals the MVE remains uninfluenced by change in posure. (2) There is modest (20%) improvement in sensitivity of detecting MVP when M\u2010mode echo is performed in standing position in addition to supine position. (3) Change in posture is preferable to the use of pharmacological maneuver to improve the sensitivity of detecting MVP because it is physiological, devoid of any cost, and does not produce side effects. (4) M\u2010mode echo in standing position or two\u2010dimensional echo in supine position can be used to confirm the diagnosis of MVP in those patients who have \u201cfalse negative\u201d and\/or nondiagnostic supine echo in the presence of auscultatory features of midsystolic click and mid\u2010 or late\u2010systolic murmurs.<\/jats:p>","DOI":"10.1002\/clc.4960081108","type":"journal-article","created":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T03:00:02Z","timestamp":1233802802000},"page":"591-596","source":"Crossref","is-referenced-by-count":2,"title":["M\u2010Mode echocardiography in supine and standing position in control subjects and patients with auscultatory evidence of mitral valve prolapse but negative supine echocardiography: Does sensitivity improve?"],"prefix":"10.1002","volume":"8","author":[{"given":"A.","family":"Ansari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.50.1.33"},{"key":"e_1_2_1_3_1","first-page":"503","article-title":"Use of echocardiography in patients with prolapsed mitral valve.","volume":"43","author":"Dillion JC","year":"1971","journal-title":"Am J Cardiol"},{"key":"e_1_2_1_4_1","first-page":"111","volume-title":"Heart Disease: A Textbook of Cardiovascular Medicine","author":"Figenbaum H","year":"1984"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.79.2.129"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197104012841303"},{"key":"e_1_2_1_7_1","first-page":"601","article-title":"Variable aspects in mitral valve prolapse. Echocardiographic and phonographic studies of 68 patients.","volume":"6","author":"Montella S","year":"1976","journal-title":"G Ital Cardiol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.82.2.158"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.49.3.428"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(77)80100-8"},{"key":"e_1_2_1_11_1","first-page":"45","article-title":"Echocardiographic recognition of mitral valve prolapse.","volume":"42","author":"Shah PM","year":"1970","journal-title":"Circulation"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960081108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960081108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T18:19:21Z","timestamp":1697825961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960081108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1985,11]]}},"alternative-id":["10.1002\/clc.4960081108"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960081108","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,11]]}}}