{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:01:09Z","timestamp":1757703669168},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":8436,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sixteen patients with metastatic carcinoid tumors of ileal or cecal origin were studied in order to evaluate the frequency and degree of cardiac involvement in a nonselected patient group. We have also studied the correlation between plasma hormone levels (e.g., 5\u2010hydroxytryptamine (5\u2010HT) and substance P) and the degree of cardiac involvement. The patients underwent physical examinations, electrocardiograms, chest x\u2010rays, cardiac catheterization, and echocardiography, Plasma levels of 5\u2010HT and substance P were analyzed. Carcinoid heart involvement was found in 3 of 16 patients (19%) but no patient had subjective symptoms associated with heart disease. Four patients (25%) had slight pulmonary hypertension. No left\u2010sided heart lesions were seen. No correlation between blood levels of 5\u2010HT or substance P and heart involvement was found. Eight patients died during the follow\u2010up period, but in none of these was the cause of death cardiac failure. Carcinoid heart disease is not as common in our patients as in patients selected on a cardiological basis described in earlier studies. Echocardioraphy appers to be the most efficient technique for detection of even subclinical heart involvement and a useful tool for following its progress.<\/jats:p>","DOI":"10.1002\/clc.4960090104","type":"journal-article","created":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T17:57:36Z","timestamp":1233856656000},"page":"13-19","source":"Crossref","is-referenced-by-count":21,"title":["Heart involvement in metastatic carcinoid disease"],"prefix":"10.1002","volume":"9","author":[{"given":"K.","family":"T\u00f6RNEBRANDT","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Eskilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nobin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)91231-0"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.20.2.208"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(75)90436-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90091-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.66.5.1059"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.57.1.128"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/003693305600100402"},{"key":"e_1_2_1_8_1","first-page":"607","article-title":"Carcinoid 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