{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:04:13Z","timestamp":1776470653323,"version":"3.51.2"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":8285,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We compared dopamine and dobutamine following cardiac surgery in a sequential cross\u2010over study of 9 patients who required inotropic support after volume replenishment. Seven patients had mitral valve replacement, 2 with simultaneous coronary revascularization (CABG), and 1 each with simultaneous tricuspid annuloplasty and aortic valve replacement; 1 had isolated CABG and 1 had repair of a postinfarction ventricular septal defect. Heart rate, right and left atrial pressures, pulmonary and mean arterial pressure, systemic and pulmonary vascular resistance, and cardiac index were measured and calculated. Inotropic support with dopamine or dobutamine was begun for treatment of low cardiac index within 12 hours postoperatively. Measurements were made after 20 minutes on either agent at 5\u201310 m\u0308g\/kg per min when cardiac output and general clinical state were stable. Each patient was then switched to the other agent at approximately the same dose rate, titrating the dosage to the same cardiac output, and repeat measurements were made at 20 minutes when again stable. Similar dosages of dopamine (6.2\u00b11.7 m\u0308g\/kg\/min) and dobutamine (6.7\u00b12.5 m\u0308g\/kg\/min) produced equivalent heart rate (103\u00b119 vs. 102\u00b113 beats\/min, p=NS), cardiac index (2.8\u00b11.1 vs. 2.9\u00b11.2 l\/min\/m<jats:sup>2<\/jats:sup>, p=NS), and pulmonary arterial pressure and vascular resistance. Mean systemic arterial pressure was significantly lower with dobutamine (59\u00b15 vs. 67\u00b17 mmHg, p&lt;0.05) as were mean left (14\u00b15 vs. 18\u00b16 mmHg, p&lt;0.0001) and right (9\u00b12 vs. 11\u00b12 mmHg, p&lt;0.05) atrial pressures. Systemic vascular resistance was also reduced with dobutamine but the difference was not statistically significant.<\/jats:p>","DOI":"10.1002\/clc.4960090604","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T03:26:22Z","timestamp":1233977182000},"page":"253-256","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of dopamine and dobutamine in patients requiring postoperative circulatory support"],"prefix":"10.1002","volume":"9","author":[{"given":"V. J.","family":"Disesa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Shemin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"J. J.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"Cohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"e_1_2_1_2_1","article-title":"The hemodynamic effect of phentolamine and dobutamine after open\u2010heart operations in children: Influence of the underlying heart defect","volume":"643","author":"Berner M","year":"1983","journal-title":"Ann Thorac Surg"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0022-5223(19)37305-2","article-title":"Hemo\u2010dynamic comparison of dopamine and dobutamine in the postoperative volume\u2010loaded, pressure\u2010loaded, and normal ventricle","volume":"83","author":"DiSesa VJ","year":"1982","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197410032911405"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.3.466"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.55.2.375"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.67.4.750"},{"key":"e_1_2_1_8_1","first-page":"108","article-title":"Postoperative enhancement of left ventricular performance by combined inotropic vasodilator therapy with preload control","volume":"88","author":"Miller DC","year":"1980","journal-title":"Surgery"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01683192"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198009000-00005"},{"key":"e_1_2_1_11_1","unstructured":"SestierF PorquetD PelletierLC:Experimental study of dobutamine and dopamine on regional contractility (abstr.).Eur Congr Cardiol June 1980"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197901043000105"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.36.1.185"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.4960090604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.4960090604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T01:35:20Z","timestamp":1697852120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.4960090604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1986,6]]}},"alternative-id":["10.1002\/clc.4960090604"],"URL":"https:\/\/doi.org\/10.1002\/clc.4960090604","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6]]}}}