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Pirmenol terminated an induced SVT in 3 of 5 patients having an atrioventricular (AV) intranodal re\u2010entry mechanism but in none of 3 patients having an atrioventricular bypass tract as one re\u2010entrant limb. The overall success in restoring sinus rhythm was 14 of 25 patients (56%). The drug was hemodynamically well tolerated even in cases of continued SVT. Pirmenol increased the atrial effective refractory period and had no obvious effect on AH and HV intervals. The functional refractory period of the AV node was decreased, probably by an anticholinergic effect. The effective and functional refractory periods of retrograde atrioventricular conduction via the AV node and bypass tract were increased in some patients. The mechanism terminating the AV intranodal SVT was a block in the retrograde part of the dual AV nodal pathway, a typical antiarrhythmic Class I effect.<\/jats:p>","DOI":"10.1002\/clc.4960090803","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T03:27:50Z","timestamp":1233977270000},"page":"369-373","source":"Crossref","is-referenced-by-count":5,"title":["Pirmenol in termination of paroxysmal supraventricular tachycardia"],"prefix":"10.1002","volume":"9","author":[{"given":"L. 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